2022: Two-year Impact Factor: 4.4
Scopus Journal Metrics
CiteScore (2022): 5.3
SJR(2022): 0.78
Open Access

Health Promot Perspect. 2020;10(4): 349-358.
doi: 10.34172/hpp.2020.53
PMID: 33312930
PMCID: PMC7722995
Scopus ID: 85098972203
  Abstract View: 914
  PDF Download: 590
  Full Text View: 336

Original Article

Association of early life factors with dyslipidemia in children and adolescents: The CASPIAN-V study

Bahareh Vard 1,2 ORCID logo, Arefeh Adham 2 ORCID logo, Roya Riahi 1, Golgis Karimi 3, Mohammad Esmail Motlagh 4, Ramin Heshmat 5, Mostafa Qorbani 6, Roya Kelishadi 1,2* ORCID logo

1 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
2 Pediatrics Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Nutrition and Dietetics, Faculty of Medicine, University Putra Malaysia, 43400 Seri Kembangan, Selangor, Malaysia
4 Pediatrics Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
*Corresponding Author: Email: roya.kelishadi@gmail.com


Background: This study aimed to investigate the association between prenatal/infancy factors and lipid profile in children and adolescents.

Methods: This multicentric national study was conducted in 30 provinces in Iran. It comprised4200 participants, aged 7-18 years, from the fifth survey of a national surveillance program. History regarding birth weight, as well as the type of consumed milk and food during infancy was obtained from parents. In addition to physical examinations, fasting blood samples were obtained to assess the lipid profile of these students.

Results: Data from 3844 participants were available (91.5% participation rate), 52.4 % of students were boys. Mean (SD) age of participants was 12.3(3.2) years. Consuming cow milk in the first two years significantly increased the risk of high triglycerides (TG) (odds ratio [OR]:2.77, 95% CI: 1.32-5.85, P: 0.01), elevated low-density lipoprotein (LDL) (P<0.05) and low high-density lipoprotein (HDL) (P <0.05). Students who had consumed commercially made food as complementary feeding were 93% more likely to have high LDL (OR: 1.93, 95%CI=1.19-3.13, P: 0.01) and 90% more likely to have high TG than students who had consumed homemade food (OR: 1.90, 95% CI: 1.15-3.12, P: 0.01). The aforementioned figures were not significantly associated with an elevated total cholesterol (TC) level.

Conclusion: Our findings revealed that the history of using human milk and home-made food as complementary feeding was associated with better lipid profile in childhood and early adolescence. Increasing public knowledge in this regard might be useful for encouragement of healthier life prevention of chronic diseases.

First Name
Last Name
Email Address
Security code

Abstract View: 897

Your browser does not support the canvas element.

PDF Download: 590

Your browser does not support the canvas element.

Full Text View: 336

Your browser does not support the canvas element.

Submitted: 15 Apr 2020
Revision: 16 Aug 2020
Accepted: 17 Aug 2020
ePublished: 07 Nov 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)