Health Promot Perspect. 2023;13(3): 183-191. doi: 10.34172/hpp.2023.22

PMID: 37808939 PMCID: PMC10558973

Systematic Review

Exploring the role of ChatGPT in patient care (diagnosis and treatment) and medical research: A systematic review

Ravindra Kumar Garg ¹ * , Vijeth L Urs ¹, Akshay Anand Agarwal ², Sarvesh Kumar Chaudhary ¹, Vimal Paliwal ³, Sujita Kumar Kar ⁴

Cited by CrossRef: 65

1- Sallam M, Barakat M, Sallam M. A Preliminary Checklist (METRICS) to Standardize the Design and Reporting of Studies on Generative Artificial Intelligence–Based Models in Health Care Education and Practice: Development Study Involving a Literature Review. Interact J Med Res. 2024;13:e54704 [Crossref]

2- Aliyeva A, Sari E, Alaskarov E, Nasirov R. Enhancing Postoperative Cochlear Implant Care With ChatGPT-4: A Study on Artificial Intelligence (AI)-Assisted Patient Education and Support. 2024; [Crossref]

3- Grimm D, Lee Y, Hu K, Liu L, Garcia O, Balakrishnan K, Ayoub N. The utility of ChatGPT as a generative medical translator. Eur Arch Otorhinolaryngol. 2024;281(11):6161 [Crossref]

4- Mirzaei T, Amini L, Esmaeilzadeh P. Clinician voices on ethics of LLM integration in healthcare: a thematic analysis of ethical concerns and implications. BMC Med Inform Decis Mak. 2024;24(1) [Crossref]

5- Alsadhan A. Assessing ChatGPT's cybersecurity implications in Saudi Arabian healthcare and education sectors: A comparative study. Nutr Health. 2024; [Crossref]

6- Rane N. Potential Role and Challenges of ChatGPT and Similar Generative Artificial Intelligence in Architectural Engineering. IJAIML. 2024;4(1):22 [Crossref]

7- Samala A, Rawas S, Wang T, Reed J, Kim J, Howard N, Ertz M. Unveiling the landscape of generative artificial intelligence in education: a comprehensive taxonomy of applications, challenges, and future prospects. Educ Inf Technol. 2024; [Crossref]

8- Rakauskas T, Da Costa A, Moriconi C, Gill G, Kwong J, Lee N. Evaluation of Chat Generative Pre-trained Transformer and Microsoft Copilot Performance on the American Society of Surgery of the Hand Self-Assessment Examinations. Journal of Hand Surgery Global Online. 2024; [Crossref]

9- Vowels L, Francois-Walcott R, Darwiche J. AI in relationship counselling: Evaluating ChatGPT's therapeutic capabilities in providing relationship advice. Computers in Human Behavior: Artificial Humans. 2024;2(2):100078 [Crossref]

10- Alqudah A, Aleshawi A, Baker M, Alnajjar Z, Ayasrah I, Ta’ani Y, Al Salkhadi M, Aljawarneh S. Evaluating accuracy and reproducibility of ChatGPT responses to patient-based questions in Ophthalmology: An observational study. 2024;103(32):e39120 [Crossref]

11- Goktas P, Grzybowski A. Assessing the Impact of ChatGPT in Dermatology: A Comprehensive Rapid Review. JCM. 2024;13(19):5909 [Crossref]

12- Mathis W, Zhao S, Pratt N, Weleff J, De Paoli S. Inductive thematic analysis of healthcare qualitative interviews using open-source large language models: How does it compare to traditional methods?. Computer Methods and Programs in Biomedicine. 2024;255:108356 [Crossref]

13- Campbell W, Chick J, Shin D, Makary M. Understanding ChatGPT for evidence-based utilization in interventional radiology. Clinical Imaging. 2024;108:110098 [Crossref]

14- Lo C, Hew K, Jong M. The influence of ChatGPT on student engagement: A systematic review and future research agenda. Computers & Education. 2024;219:105100 [Crossref]

15- Ahmed S. The future of oral cancer care: Integrating ChatGPT into clinical practice. Oral Oncology Reports. 2024;10:100317 [Crossref]

16- Snigdha N, Batul R, Karobari M, Adil A, Dawasaz A, Hameed M, Mehta V, Noorani T, Tatu A. Assessing the Performance of ChatGPT 3.5 and ChatGPT 4 in Operative Dentistry and Endodontics: An Exploratory Study. Human Behavior and Emerging Technologies. 2024;2024(1) [Crossref]

17- Li M, Guenier A. ChatGPT and Health Communication. 2024;15(1):1 [Crossref]

18- Choi J, Han E, Yoo T. Application of ChatGPT-4 to oculomics: a cost-effective osteoporosis risk assessment to enhance management as a proof-of-principles model in 3PM. EPMA Journal. 2024;15(4):659 [Crossref]

19- Hu Y, Hu Z, Liu W, Gao A, Wen S, Liu S, Lin Z. Exploring the potential of ChatGPT as an adjunct for generating diagnosis based on chief complaint and cone beam CT radiologic findings. BMC Med Inform Decis Mak. 2024;24(1) [Crossref]

20- de Araújo Lopes N, Nonaka C, Alves P, Cunha J. Will artificial intelligence chatbots revolutionize the way patients with oral diseases access information?. Journal of Stomatology, Oral and Maxillofacial Surgery. 2024;125(3):101703 [Crossref]

21- Yüce A, Yerli M, Misir A, Çakar M. Enhancing patient information texts in orthopaedics: How OpenAI's ‘ChatGPT’ can help. J exp orthop. 2024;11(3) [Crossref]

22- Sengupta P, Dutta S, Chakravarthi S, Jegasothy R, Jeganathan R, Pichumani A. Comparative efficacy of ChatGPT 3.5, ChatGPT 4, and other large language models in gynecology and infertility research. gocm. 2023;3(4):203 [Crossref]

23- Denecke K, May R, Rivera Romero O. Potential of Large Language Models in Health Care: Delphi Study. J Med Internet Res. 2024;26:e52399 [Crossref]

24- Ding Z, Wei R, Xia J, Mu Y, Wang J, Lin Y. Exploring the potential of large language model–based chatbots in challenges of ribosome profiling data analysis: a review. 2024;26(1) [Crossref]

25- Zheng J, Ding X, Pu J, Chung S, Ai Q, Hung K, Shan Z. Unlocking the Potentials of Large Language Models in Orthodontics: A Scoping Review. Bioengineering. 2024;11(11):1145 [Crossref]

26- Hess B, Cupido N, Ross S, Kvern B. Becoming adaptive experts in an era of rapid advances in generative artificial intelligence. Medical Teacher. 2024;46(3):300 [Crossref]

27- Criss S, Nguyen T, Gonzales S, Lin B, Kim M, Makres K, Sorial B, Xiong Y, Dennard E, Merchant J, Hswen Y. “HIV Stigma Exists” — Exploring ChatGPT’s HIV Advice by Race and Ethnicity, Sexual Orientation, and Gender Identity. J Racial and Ethnic Health Disparities. 2024; [Crossref]

28- Drouaud A, Stocchi C, Tang J, Gonsalves G, Cheung Z, Szatkowski J, Forsh D. Exploring the Performance of ChatGPT in an Orthopaedic Setting and Its Potential Use as an Educational Tool. 2024;9(4) [Crossref]

29- Gupta P, Ding B, Guan C, Ding D. Generative AI: A systematic review using topic modelling techniques. Data and Information Management. 2024;8(2):100066 [Crossref]

30- Borna S, Gomez-Cabello C, Pressman S, Haider S, Forte A. Comparative Analysis of Large Language Models in Emergency Plastic Surgery Decision-Making: The Role of Physical Exam Data. JPM. 2024;14(6):612 [Crossref]

31- Khalifa M, Albadawy M. Using artificial intelligence in academic writing and research: An essential productivity tool. Computer Methods and Programs in Biomedicine Update. 2024;5:100145 [Crossref]

32- Lo C, Yu P, Xu S, Ng D, Jong M. Exploring the application of ChatGPT in ESL/EFL education and related research issues: a systematic review of empirical studies. Smart Learn Environ. 2024;11(1) [Crossref]

33- Choi J, Oh A, Park J, Kang R, Yoo S, Lee D, Yang K. Evaluation of the quality and quantity of artificial intelligence-generated responses about anesthesia and surgery: using ChatGPT 3.5 and 4.0. Front Med. 2024;11 [Crossref]

34- Momenaei B, Mansour H, Kuriyan A, Xu D, Sridhar J, Ting D, Yonekawa Y. ChatGPT enters the room: what it means for patient counseling, physician education, academics, and disease management. 2024;35(3):205 [Crossref]

35- Bartal A, Jagodnik K, Chan S, Dekel S. AI and narrative embeddings detect PTSD following childbirth via birth stories. Sci Rep. 2024;14(1) [Crossref]

36- Chung D, Sidhom K, Dhillon H, Bal D, Fidel M, Jawanda G, Patel P. Real-world utility of ChatGPT in pre-vasectomy counselling, a safe and efficient practice: a prospective single-centre clinical study. World J Urol. 2024;43(1) [Crossref]

37- Ahimaz P, Bergner A, Florido M, Harkavy N, Bhattacharyya S. Genetic counselors' utilization of ChatGPT in professional practice: A cross‐sectional study. American J of Med Genetics Pt A. 2024;194(4) [Crossref]

38- Lack B, Mouhawasse E, Childers J, Jackson G, Daji S, Yerke-Hansen P, Familiari F, Knapik D, Sabesan V. Can ChatGPT answer patient questions regarding reverse shoulder arthroplasty?. Journal of ISAKOS. 2024;9(6):100323 [Crossref]

39- Hadar-Shoval D, Asraf K, Shinan-Altman S, Elyoseph Z, Levkovich I. Embedded values-like shape ethical reasoning of large language models on primary care ethical dilemmas. Heliyon. 2024;10(18):e38056 [Crossref]

40- Carni M, Gur T, Maaravi Y. Entrepreneurs’ Social Capital in Overcoming Business Challenges: Case Studies of Seven Greentech, Climate Tech and Agritech Startups. Sustainability. 2024;16(19):8371 [Crossref]

41- Levin C, Kagan T, Rosen S, Saban M. An evaluation of the capabilities of language models and nurses in providing neonatal clinical decision support. International Journal of Nursing Studies. 2024;155:104771 [Crossref]

42- Shojaei P, Khosravi M, Jafari Y, Mahmoudi A, Hassanipourmahani H. ChatGPT utilization within the building blocks of the healthcare services: A mixed-methods study. DIGITAL HEALTH. 2024;10 [Crossref]

43- Jaques A, Abdelghafour K, Perkins O, Nuttall H, Haidar O, Johal K. A Study of Orthopedic Patient Leaflets and Readability of AI-Generated Text in Foot and Ankle Surgery (SOLE-AI). 2024; [Crossref]

44- Fiegler-Rudol J, Kronenberg M, Męcik-Kronenberg T. Novel ways of applying artificial intelligence in emergency medicine - literature review. Emerg Med Serv. 2024;11(2):132 [Crossref]

45- Youssef Y, Youssef S, Melcher P, Henkelmann R, Osterhoff G, Theopold J. How accurately can ChatGPT 3.5 answer frequently asked questions by patients on glenohumeral osteoarthritis?. Obere Extremität. 2024; [Crossref]

46- Brochu B, Mirsky N, Thaller S. Evaluating ChatGPT’s efficacy in addressing common patient questions in plastic surgery consultations. Art Int Surg. 2024;4(4):411 [Crossref]

47- Ourang S, Sohrabniya F, Mohammad‐Rahimi H, Dianat O, Aminoshariae A, Nagendrababu V, Dummer P, Duncan H, Nosrat A. Artificial intelligence in endodontics: Fundamental principles, workflow, and tasks. Int Endodontic J. 2024;57(11):1546 [Crossref]

48- Abdalla A, Aziz T. ChatGPT: A game-changer in oral and maxillofacial surgery. Journal of Medicine, Surgery, and Public Health. 2024;2:100078 [Crossref]

49- Lee Y, Kim S. Potential applications of ChatGPT in obstetrics and gynecology in Korea: a review article. Obstet Gynecol Sci. 2024;67(2):153 [Crossref]

50- Yavuz Y, Kahraman F. Evaluation of the prediagnosis and management of ChatGPT-4.0 in clinical cases in cardiology. Future Cardiology. 2024;20(4):197 [Crossref]

51- Mourtajji L, Arts-Chiss N. Unleashing ChatGPT: Redefining Technology Acceptance and Digital Transformation in Higher Education. Administrative Sciences. 2024;14(12):325 [Crossref]

52- Gur T, Hameiri B, Maaravi Y. Political ideology shapes support for the use of AI in policy-making. Front Artif Intell. 2024;7 [Crossref]

53- Mo Y, Park H, Jang J, Lee E. Relative importance of “why” and “how” messages on medication behavior: Insights from construal level theory. Patient Education and Counseling. 2025;132:108603 [Crossref]

54- Mondal H, Komarraju S, D S, Muralidharan S. Assessing the Capability of Large Language Models in Naturopathy Consultation. 2024; [Crossref]

55- Shamil E, Ko T, Fan K, Schuster-Bruce J, Jaafar M, Khwaja S, Eynon-Lewis N, D'Souza A, Andrews P. Assessing the Quality and Readability of Online Patient Information: ENT UK Patient Information e-Leaflets versus Responses by a Generative Artificial Intelligence. Facial Plast Surg. 2024; [Crossref]

56- Sireci F, Lorusso F, Immordino A, Centineo M, Gerardi I, Patti G, Rusignuolo S, Manzella R, Gallina S, Dispenza F. ChatGPT as a New Tool to Select a Biological for Chronic Rhino Sinusitis with Polyps, “Caution Advised” or “Distant Reality”?. JPM. 2024;14(6):563 [Crossref]

57- Seth I, Lim B, Phan R, Xie Y, Kenney P, Bukret W, Thomsen J, Cuomo R, Ross R, Ng S, Rozen W. Perforator Selection with Computed Tomography Angiography for Unilateral Breast Reconstruction: A Clinical Multicentre Analysis. Medicina. 2024;60(9):1500 [Crossref]

58- Barua M. Assessing the Performance of ChatGPT in Answering Patients’ Questions Regarding Congenital Bicuspid Aortic Valve. 2024; [Crossref]

59- Sun D, Hadjiiski L, Gormley J, Chan H, Caoili E, Cohan R, Alva A, Bruno G, Mihalcea R, Zhou C, Gulani V. Outcome Prediction Using Multi-Modal Information: Integrating Large Language Model-Extracted Clinical Information and Image Analysis. Cancers. 2024;16(13):2402 [Crossref]

60- Saad A, Rahij H, Durgaprasad B, Iyengar K, Botchu R. Assessing Chat Generative Pre-training Transformer’s Proficiency in Identifying, Diagnosing, and Managing Orthopedic Fractures. 2025;12(1):27 [Crossref]

61- Abdulnazar A, Roller R, Schulz S, Kreuzthaler M. Large Language Models for Clinical Text Cleansing Enhance Medical Concept Normalization. IEEE Access. 2024;12:147981 [Crossref]