Health Promot Perspect. 2020;10(1): 3-4. doi: 10.15171/hpp.2020.02

PMID: 32104650 PMCID: PMC7036208

Letter to Editor

Postbiotics as novel health-promoting ingredients in functional foods

Aziz Homayouni Rad ¹ , Leili Aghebati Maleki ² , Hossein Samadi Kafil ³ , Hamideh Fathi Zavoshti ¹ , Aamin Abbasi ^1,4 *

Cited by CrossRef: 62

1- Cabello Córdova L. Los productos bióticos, definición y modo de acción. ALPA. 2022;30(Supl. 1):55 [Crossref]

2- Bolívar-Jacobo N, Reyes-Villagrana R, Espino-Solís G, Rentería-Monterrubio A, Arévalos-Sánchez M, Sánchez-Vega R, Santellano-Estrada E, Chávez-Flores D, Chávez-Martínez A. The Effects of a High-Intensity Ultrasound on the Fermentative Activity and Kinetic Growth of Lactobacillus Acidophilus and Lactobacillus Helveticus. Fermentation. 2023;9(4):356 [Crossref]

3- Feng L, Guo Z, Zhao J, Yao W, Li X, Wu L, Mu G, Zhu X. Screening of anti-allergic Lactiplantibacillus species by splenocyte sensitization model and evaluate their probiotic and postbiotic characteristics. Food Bioscience. 2024;57:103440 [Crossref]

4- Hu A, Huang W, Shu X, Ma S, Yang C, Zhang R, Xiao X, Wu Y. Lactiplantibacillus plantarum Postbiotics Suppress Salmonella Infection via Modulating Bacterial Pathogenicity, Autophagy and Inflammasome in Mice. Animals. 2023;13(20):3215 [Crossref]

5- Homayouni-Rad A, Pouragha B, Houshyar J, Soleimani R, Kazemi S, Keisan S, Akhlaghi A. Postbiotic Application: A Review on Extraction, Purification, and Characterization Methods. Food Bioprocess Technol. 2024; [Crossref]

6- Abbasi A, Hajipour N, Hasannezhad P, Baghbanzadeh A, Aghebati-Maleki L. Potential in vivo delivery routes of postbiotics. Critical Reviews in Food Science and Nutrition. 2022;62(12):3345 [Crossref]

7- Nasri F, Alizadeh A, İncili G, Hayaloğlu A, Moradi M. Investigating Chemical Composition and Functionality of Lactobacillus acidophilus LA-5 Postbiotics Prepared in Classic and Cheese Whey Media. Probiotics & Antimicro Prot. 2024; [Crossref]

8- Sun S, Zhang Q, Li D, Li H, Ma H, Wu X, Li Y, Wang P, Liu R, Feng H, Zhang Y, Sang Y, Fang B, Wang R. Heat-killed Bifidobacterium longum BBMN68 and inulin protect against high-fat diet-induced obesity by modulating gut microbiota. Front Nutr. 2024;11 [Crossref]

9- Isaac-Bamgboye F, Mgbechidinma C, Onyeaka H, Isaac-Bamgboye I, Chukwugozie D, Sahar A. Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement. Journal of Nutrition and Metabolism. 2024;2024(1) [Crossref]

10- Homayouni Rad A, Aghebati Maleki L, Samadi Kafil H, Fathi Zavoshti H, Abbasi A. Postbiotics as Promising Tools for Cancer Adjuvant Therapy. Adv Pharm Bull. 2020;11(1):1 [Crossref]

11- Kapustian A, Cherno N, Naumenko K, Gural L, Osolina S. REGULATION OF FUNCTIONAL FOODS IN UKRAINE AND THE WORLD. PROSPECTS FOR THE USE OF POSTBIOTICS AS FUNCTIONAL INGREDIENTS. FST. 2023;17(2) [Crossref]

12- Zhong Y, Liu Z, Wang Y, Cai S, Qiao Z, Hu X, Wang T, Yi J. Preventive Methods for Colorectal Cancer Through Dietary Interventions: A Focus on Gut Microbiota Modulation. Food Reviews International. 2024;:1 [Crossref]

13- sadeghzadeh J, Jafarzadeh J, Hadinezhad P, Nazari A, Sohrabi S, Musazadeh V, Barzegar A, Shahabi P. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International Immunopharmacology. 2023;120:110314 [Crossref]

14- Cui H, Feng C, Guo C, Duan Z. Development of Novel Topical Anti-Acne Cream Containing Postbiotics for Mild-to-Moderate Acne. 2022;67(6):667 [Crossref]

15- Narli M, Ozcan T. Assessment of bifidogenic potential of cowpea (Vigna unguiculata (L.) Walp.) extract in in vitro and milk fermentation models. LWT. 2022;157:113071 [Crossref]

16- Zafar I, Hussain A, Fatima T, Abdullah Alnasser S, Ahmad A. Inter-Varietal Variation in Phenolic Profile, Sugar Contents, Antioxidant, Anti-Proliferative and Antibacterial Activities of Selected Brassica Species. Applied Sciences. 2022;12(12):5811 [Crossref]

17- Yadav M, Yadav S, Shukla P. Probiotic potential of Weissella paramesenteroides MYPS5.1 isolated from customary dairy products and its therapeutic application. 3 Biotech. 2022;12(1) [Crossref]

18- GÖKIRMAKLI Ç, ÜÇGÜL B, SEYDİM Z. FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. 2021;46(4):872 [Crossref]

19- Soleimani R, Shokouhian S, Houshyar J, Khani N, Abachi S, Milani P, Panahi E, Homayouni-Rad A. Postbiotic Bioactive Packaging Systems: A Review. CNF. 2024;20(3):296 [Crossref]

20- Özcan T, Özcan M. Fermented milk cream and its properties. Food Health. 2022;8(1):78 [Crossref]

21- Harat S, Pourjafar H. Health Benefits and Safety of Postbiotics Derived from Different Probiotic Species. CPD. 2025;31(2):116 [Crossref]

22- Vilhelmova-Ilieva N, Danova S, Petrova Z, Dobreva L, Atanasov G, Mancheva K, Simeonova L. Protective and Therapeutic Capacities of Lactic Acid Bacteria Postmetabolites against Koi Herpesvirus Infection In Vitro. Life. 2023;13(3):739 [Crossref]

23- Nezhadi J, Ahangarzadeh Rezaee M, Asghari Ozma M, Ganbarov K, Samadi Kafil H. Gut Microbiota Exchange in Domestic Animals and Rural-urban People Axis. CPB. 2024;25(7):825 [Crossref]

24- Ye H, Liu X, Guan K, Ma Y, Liu R, Liu Y, Lv X, Wang R, Li Q. Therapeutic potential of Lacticaseibacillus rhamnosus grx10 and its derived postbiotic through gut microbiota and MAPK/MLCK/MLC pathway‐mediated intestinal barrier repairment in ulcerative colitis. Journal of Food Science. 2024; [Crossref]

25- Dinu L, Avram I, Pelinescu D, Vamanu E. Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis. Biomedicines. 2022;10(10):2392 [Crossref]

26- Rad A, Abbasi A, Kafil H, Ganbarov K. Potential Pharmaceutical and Food Applications of Postbiotics: A Review. CPB. 2020;21(15):1576 [Crossref]

27- Sabahi S, Homayouni Rad A, Aghebati-Maleki L, Sangtarash N, Ozma M, Karimi A, Hosseini H, Abbasi A. Postbiotics as the new frontier in food and pharmaceutical research. Critical Reviews in Food Science and Nutrition. 2023;63(26):8375 [Crossref]

28- Sepordeh S, Jafari A, Bazzaz S, Abbasi A, Aslani R, Houshmandi S, Rad A. Postbiotic as Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry. CPB. 2024;25(10):1245 [Crossref]

29- Wu Y, Wang Y, Hu A, Shu X, Huang W, Liu J, Wang B, Zhang R, Yue M, Yang C. Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut–brain axis in mice. Front Nutr. 2022;9 [Crossref]

30- Buccigrossi V, Poeta M, Cioffi V, Terranova S, Nunziata F, Lo Vecchio A, Guarino A. Lacticaseibacillus rhamnosus GG Counteracts Rotavirus-Induced Ion Secretion and Enterocyte Damage by Inhibiting Oxidative Stress and Apoptosis Through Specific Effects of Living and Postbiotic Preparations. Front Cell Infect Microbiol. 2022;12 [Crossref]

31- Dewanjee S, Dua T, Paul P, Dey A, Vallamkondu J, Samanta S, Kandimalla R, De Feo V. Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity. Biomedicines. 2022;10(7):1498 [Crossref]

32- Reuben R, Sarkar S, Roy P, Anwar A, Hossain M, Jahid I. Prebiotics, probiotics and postbiotics for sustainable poultry production. World's Poultry Science Journal. 2021;77(4):825 [Crossref]

33- Pirhadi M, Alikord M, Aman mohammadi M, Shariatifar N. Beneficial Effects of Post-biotics on Food Products and its Effect on Human Health: a Critical Review. Plant Biotechnol Persa. 2021;3(2):56 [Crossref]

34- Homayouni Rad A, Aghebati Maleki L, Samadi Kafil H, Abbasi A. Postbiotics: A novel strategy in food allergy treatment. Critical Reviews in Food Science and Nutrition. 2021;61(3):492 [Crossref]

35- Amini Khiabani S, Haghighat S, Tayebi Khosroshahi H, Asgharzadeh M, Samadi Kafil H. Diversity of Bacteroidaceae family in gut microbiota of patients with chronic kidney disease and end stage renal disease. Health Promot Perspect. 2023;13(3):237 [Crossref]

36- Di Costanzo M, Carucci L, Berni Canani R, Biasucci G. Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies. IJMS. 2020;21(15):5275 [Crossref]

37- Zoghi S, Abbasi A, Heravi F, Somi M, Nikniaz Z, Moaddab S, Ebrahimzadeh Leylabadlo H. The gut microbiota and celiac disease: Pathophysiology, current perspective and new therapeutic approaches. Critical Reviews in Food Science and Nutrition. 2024;64(8):2176 [Crossref]

38- Volentini S, Olmedo G, Grillo-Puertas M, Rapisarda V, Hebert E, Cerioni L, Villegas J. Biological control of green and blue molds on postharvest lemon by lactic acid bacteria. Biological Control. 2023;185:105303 [Crossref]

39- Chiu Y, Chiu H, Lin M. Synergistic effect of probiotic and postbiotic on attenuation of PM2.5‐induced lung damage and allergic response. Journal of Food Science. 2023;88(1):513 [Crossref]

40- Da M, Sun J, Ma C, Li D, Dong L, Wang L, Chen F. Postbiotics: Enhancing human health with a novel concept. eFood. 2024;5(5) [Crossref]

41- Ailioaie L, Litscher G. Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges. IJMS. 2021;22(9):4942 [Crossref]

42- Homayouni Rad A, Pourjafar H, Mirzakhani E. A comprehensive review of the application of probiotics and postbiotics in oral health. Front Cell Infect Microbiol. 2023;13 [Crossref]

43- Majeed M, Majeed S, Nagabhushanam K, Mundkur L, Rajalakshmi H, Shah K, Beede K. Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety. Cosmetics. 2020;7(3):70 [Crossref]

44- Homayouni-Rad A, Abbasi A, Soleimani R, Pouraga B. Could Postbiotics Substitute Probiotics?. CNF. 2023;19(7):670 [Crossref]

45- Bolivar Jacobo N, Reyes Villagrana R, Chávez-Martínez A. Relación entre probióticos - postbióticos y sus principales efectos bioactivos . tecnociencia. 2021;15(2):124 [Crossref]

46- Yan R, Zeng X, Shen J, Wu Z, Guo Y, Du Q, Tu M, Pan D. New clues for postbiotics to improve host health: a review from the perspective of function and mechanisms. J Sci Food Agric. 2024;104(11):6376 [Crossref]

47- Abbasi A, Rad A, Maleki L, Kafil H, Baghbanzadeh A. Antigenotoxicity and Cytotoxic Potentials of Cell-Free Supernatants Derived from Saccharomyces cerevisiae var. boulardii on HT-29 Human Colon Cancer Cell Lines. Probiotics & Antimicro Prot. 2023;15(6):1583 [Crossref]

48- Sheykhsaran E, Abbasi A, Ebrahimzadeh Leylabadlo H, Sadeghi J, Mehri S, Naeimi Mazraeh F, Feizi H, Bannazadeh Baghi H. Gut microbiota and obesity: an overview of microbiota to microbial-based therapies. 2023;99(1171):384 [Crossref]

49- Abbasi A, Rad A, Ghasempour Z, Sabahi S, Kafil H, Hasannezhad P, Rahbar Saadat Y, Shahbazi N. The biological activities of postbiotics in gastrointestinal disorders. Critical Reviews in Food Science and Nutrition. 2022;62(22):5983 [Crossref]

50- Abbasi A, Aghebati-Maleki L, Homayouni-Rad A. The promising biological role of postbiotics derived from probiotic Lactobacillus species in reproductive health. Critical Reviews in Food Science and Nutrition. 2022;62(32):8829 [Crossref]

51- Huang H, Lai C, Tsai W, Chen K, Peng S, Lin J, Lin Y. Nanoparticle-enhanced postbiotics: Revolutionizing cancer therapy through effective delivery. Life Sciences. 2024;337:122379 [Crossref]

52- Mohajeri M, Mohajery R, Nemati A, Pourfarzi F. The difference in the dietary inflammatory index, functional food, and antioxidants intake between COVID -19 patients and healthy persons. MNM. 2022;15(2):219 [Crossref]

53- Zyaynitdinov D, Evteev A, Bannikova A. Properties of Polyphenols and Xylooligosaccharides Obtained Biotechnologically from Processed Millets. 2021;:538 [Crossref]

54- Rad A, Aghebati-Maleki L, Kafil H, Abbasi A. Molecular mechanisms of postbiotics in colorectal cancer prevention and treatment. Critical Reviews in Food Science and Nutrition. 2021;61(11):1787 [Crossref]

55- Zhong Y, Wang T, Luo R, Liu J, Jin R, Peng X. Recent advances and potentiality of postbiotics in the food industry: Composition, inactivation methods, current applications in metabolic syndrome, and future trends. Critical Reviews in Food Science and Nutrition. 2024;64(17):5768 [Crossref]

56- Abbasi A, Aghebati-Maleki A, Yousefi M, Aghebati-Maleki L. Probiotic intervention as a potential therapeutic for managing gestational disorders and improving pregnancy outcomes. Journal of Reproductive Immunology. 2021;143:103244 [Crossref]

57- Khani N, Bonyadi M, Soleimani R, Raziabad R, Ahmadi M, Homayouni-Rad A. Postbiotics: As a Promising Tools in the Treatment of Celiac Disease. Probiotics & Antimicro Prot. 2024; [Crossref]

58- Ghaffari S, Abbasi A, Somi M, Moaddab S, Nikniaz L, Kafil H, Ebrahimzadeh Leylabadlo H. Akkermansia muciniphila : from its critical role in human health to strategies for promoting its abundance in human gut microbiome . Critical Reviews in Food Science and Nutrition. 2023;63(25):7357 [Crossref]

59- Mohajeri M. The association of dietary inflammatory index, functional foods and some antioxidants intake with COVID-19 vaccine side effects in Iranian adults. NFS. 2022;52(8):1197 [Crossref]

60- Khani N, Shkouhian S, Kafil H, Gilani N, Abbasi A, Rad A. Assessing the growth-inhibitory activity of postbiotics of Lactobacillus spp. against Staphylococcus aureus under in vitro circumstances and food model. 2023;76(2) [Crossref]

61- Pirhadi M, Khaniki G, Nejad A, Sadighara P. The Effect of Postbiotics On Depressive Symptoms and Polycystic Ovary Syndrome (PCOS) in Human Health: A Short Review. CWHR. 2023;19(3) [Crossref]

62- Ozma M, Moaddab S, Hosseini H, Khodadadi E, Ghotaslou R, Asgharzadeh M, Abbasi A, Kamounah F, Aghebati Maleki L, Ganbarov K, Samadi Kafil H. A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics. Critical Reviews in Food Science and Nutrition. 2023;:1 [Crossref]