Weather fluctuations: predictive factors in the prevalence of acute coronary syndrome

Health Promotion Perspectives, 9(2), 123-130; DOI:10.15171/hpp.2019.17

Original Article

Weather fluctuations: predictive factors in the prevalence of acute coronary syndrome

Hamid Sharif Nia1, Yiong Huak Chan2, Erika Sivarajan Froelicher3, Saeed Pahlevan Sharif4, Ameneh Yaghoobzadeh5, Azar Jafari6, Amir Hossein Goudarzian7 ,*, Roghiyeh Pourkia8, Ali Akbar Haghdoost9, Farhad Arefinia10, Roghieh Nazari1

1 Department of Medical-Surgical Nursing, School of Nursing and Midwifery Amol, Mazandaran University of Medical Sciences, Sari, Iran
2 Biostatistics Unit, Yong Loo Lin School of Medicine, National University Health System, Singapore
3 Department of Physiological Nursing, Department of Epidemiology & Biostatistics, University of California San Francisco, California, USA
4 Taylor’s Business School, Taylor’s University Malaysia, Subang Jaya, Malaysia
5 Department of Nursing, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Nursing, Mazandaran University of Medical Sciences, Sari, Iran
7 Faculty of Nursing, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
8 Department of Cardiology, Cardiovascular Research Center, Babol University of Medical Sciences, Babol, Iran
9 Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
10 School of Nursing and Midwifery Amol, Mazandaran University of Medical Sciences, Sari, Iran

Email: amir_sari@yahoo.com

© 2019 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Meteorological parameters and seasonal changes can play an important role in the occurrence of acute coronary syndrome (ACS). However, there is almost no evidence on a national level to suggest the associations between these variables and ACS in Iran. We aim to identify the meteorological parameters and seasonal changes in relationship to ACS. Methods: This retrospective cross-sectional study was conducted between 03/19/2015 to 03/18/2016 and used documents and records of patients with ACS in Mazandaran ProvinceHeart Center, Iran. The following definitive diagnostic criteria for ACS were used: (1) existence of cardiac enzymes (CK or CK-MB) above the normal range; (2) Greater than 1 mm ST-segment elevation or depression; (3) abnormal Q waves; and (4) manifestation of troponin enzyme in the blood. Data were collected daily, such as temperature (Celsius) changes, wind speed and its direction, rainfall, daily evaporation rate; number of sunny days, and relative humidity were provided by the Meteorological Organization of Iran. Results: A sample of 2,054 patients with ACS were recruited. The results indicated the highest ACS events from March to May. Generally, wind speed (18 PM) [IRR = 1.051 (95% CI: 1.019 to1.083), P=0.001], daily evaporation [IRR = 1.039 (95% CI: 1.003 to 1.077), P=0.032], daily maximum (P<0.001) and minimum (P=0.003) relative humidity was positively correlated withACS events. Also, negatively correlated variables were daily relative humidity (18 PM) [IRR =0.985 (95% CI: 0.978 to 0.992), P<0.001], and daily minimum temperature [IRR = 0.942 (95%CI: 0.927 to 0.958), P<0.001]. Conclusion: Climate changes were found to be significantly associated with ACS; especially from cold weather to hot weather in March, April and May. Further research is needed to fully understand the specific conditions and cold exposures.

Keywords: Meteorological parameters, Seasonal changes, Acute coronary syndrome, Prevalence, Iran

Citation: Sharif Nia H, Chan YH, Froelicher ES, Pahlevan Sharif S, Yaghoobzadeh A, Jafari A, et al. Weather fluctuations: predictive factors in the prevalence of acute coronary syndrome. Health Promot Perspect. 2019;9(2):123-130. doi: 10.15171/hpp.2019.17.


Acute coronary syndrome (ACS) is one of the most common health problems in the world, which can increase mental health problems, result in considerable disability, increase morbidity, and mortality.1,2 Studies during several decades have focused on different pathophysiological mechanisms and predisposing factors for the incidence of ACS.3-5 One of these studies focused on the effects of weather conditions on incidence of ACS that has been discussed in different areas of the world for more than 50 years.6 A number of investigators found that meteorological parameters and seasonal changes can play an important role in the occurrence of ACS.7,8 The role of temperature is both direct and fast. Time series studies have revealed that there is a minimum lag time of about 24 hours between decrease in temperature and increase in mortality.9 The study reported that approximately 4% of ACS onsets are associated with different kinds of meteorological parameters.10 In another study, it was found that weather conditions like atmospheric air temperature, humidity, wind speed, and wind pressure effects the incidence of ACS.11-13 Although several studies suggest that ACS occurs most often in the winter months,14-17 other studies report that the occurrence rate of ACS increases in spring.6,18 Yet another study shows that ACS occurs in summer when the temperature and humidity are high and atmospheric pressure is low.19 It has also been shown that there is an association between temperature, high relative humidity, and strong winds and ACS.9 It seems that physiologic stressors such as sympathetic activation, hypercoagulability and infection in cold weather condition (such as influenza epidemics and air pollution) are linked to the incidence of ACS.20 Additionally, hemodynamic changes are exacerbated during winter, as are elevated immune reactions, uncontrolled hypertension, immobility, and risk for respiratory infections,21 that can affect the incidence of ACS. Some studies state that cold temperature effects platelet numbers, arterial blood pressure, and thrombus formation.19 Also, variation of incidence of ACS in different seasons is attributed to variability in ultraviolet-B exposure during the seasons and vitamin D deficiency that may increase the cardiovascular risk.22 Nevertheless, a 1°C decrease in temperature caused a 1%–2% rise in the number of deaths.9

Although‏ numerous‏ studies‏ have‏ been‏ conducted‏ on‏ the impact of climate variables and seasonal changes on the risk of ACS in different areas of the world; many of these studies lack national level data. However, there is almost no evidence to suggest an association between climate variables and the risk of ACS in Iran. So, due to the importance of reducing the incidence of ACS and its effects on quality of life, it is important to study the impact of meteorological parameters and seasonal changes on the incidence of ACS in a region with different weather conditions and great geographic diversity. In other words, a better understanding of the seasonal changes may provide novel pathways to prevent ACS.23 Therefore, the present study aims to determine the relationship between meteorological parameters with the incidence of ACS.

Materials and Methods

This retrospective cross-sectional study design was used. This study is based on medical records of the Heart Center of Mazandaran province, Iran. This center provides the most comprehensive data in northern Iran on all patients with a diagnosis of ACS.


The Mazandaran Province Heart Center, Iran located at the following coordinates (36.369 N, 52.270 W) was chosen because it offers the most complete data in Iran about patients diagnosed with ACS.24 Census sampling method was used. Existing date was used between 03/19/2015 to 03/18/2016. Sari (the capital of Mazandaran) is a north city of Iran which has mild weather. Based on the newest census in 2016, it contains the 505 000 inhabitants. The center consists of five CCU wards, one ICU, and one emergency ward. Registered data of the ACS patients surveyed are used from these units.

Study population

The current study was carried out among all patients referred to the hospital with symptoms of ACS. The cardiologist, two nurses, a statistician, and an epidemiologist (who extracted and recorded the needed information using a data collection guide) formed the research team. The final diagnosis of ACS was verified by the cardiologist. The following were considered as the definitive diagnostic criteria were: (1) existence of cardiac enzymes (CK or CK-MB) above the normal range; (2) ST-segment elevation or depression of more than 1; (3) abnormal Q waves; and (4) manifestation of Troponin enzyme in the blood.2

Two nurses invited patients to participate in the study after the ethical approval of the study had been obtained from the Mazandaran University of Medical Sciences.


The following variables were abstracted: gender, the day, month, year and time of hospital admission. Also, weather variables were included daily temperature (Celsius) changes (minimum, maximum, and average), wind speed (meters per second) and its direction, rainfall (day), daily evaporation rate (mm), number of sunny days, and relative humidity (percent) between March 2015 to March 2016 were provided by the Meteorological Organization of Iran. Iran’s four climate seasons are: spring (April to June), summer (July to September), autumn (September to December) and winter (January to March).

Statistical analysis

All analyses were performed using SPSS 24.0 (SPSS 24.0, Inc., Chicago, Illinois, USA) with statistical significance set at α = 0.05. Mean (SD) were presented for numeric normal variables, median (range) for numeric non-normal variables and frequency (%) for categorical variables. General Linear Model was performed to compare the number of ACS events across months adjusting for age, gender and meteorological variables with Bonferroni correction for pairwise comparisons. A negative binomial regression model accounting for over-dispersion was used to determine the meteorological (daily temperature (minimum, maximum, and average), wind speed and its direction, rainfall, daily evaporation rate, number of sunny days, and relative humidity) and demographical predictors on daily (defining a day from 00:00 to 23:59 hours) relative risk (RR) ACS prevalence with a 95% confidence interval, gender-subgroup analyses was also performed.


Sample characteristics

Over the study period, a total of 2054 patients with ACS were recruited. The mean (±SD) age of the subjects was 55.6 (±13.4), median 58 and their ages ranged from 20 to 91 years old, with 49.3% being men. The ages for men were mean (±SD) 56.3 (±13.3), median 58, ranging between 20-91 and 55.0 (±13.5), 57, 20-91 for women. Table 1 shows the descriptive statistics for the meteorological variables.

Table 1. Meteorological variables descriptive
Variable Mean (SD) Range Median
Wind speed 4.62 (2.36) 0–20 4.0
Wind speed (18 PM) 1.23 (1.71) 0–18 0.0
Wind speed (12 MD) 2.22 (1.67) 0–8 2.0
Wind speed (6 AM) 0.72 (1.26) 0–8 0.0
Daily evaporation 2.79 (2.27) 0–9.6 2.2
Daily rain 1.62 (5.68) 0–69.9 0.0
Daily relative humidity (18 pm) 79.57 (11.75) 26–98 82.0
Daily Relative humidity (12 md) 66.15 (15.98) 26–100 64.0
Daily Relative humidity (6 am) 89.42 (9.14) 30–100 92.0
Daily average relative humidity 78.03 (9.39) 47.5–98.5 78.0
Daily maximum relative humidity 95.11 (4.33) 72–100 97.0
Daily minimum relative humidity 60.95 (16.65) 23–97 60.0
Daily average temperature 16.71 (7.06) 5.5–33.3 15.0
Maximum daily temperature 21.36 (7.99) 7.4–42.6 19.6

Weather fluctuations

Figures 1 and 2 show the number of ACS events by gender and by age in quartiles for each month, respectively.

Figure 1. Number of AMI events by gender over month.

Figure 2. Number of AMI events by age quartiles over month.

Figures 1 and 2 show that the third to the fifth months had statistically higher (P < 0.001) occurrences of ACS events during the year. Overall the other months except for month 5 over month 1 (P = 0.581) adjusting for demographical and meteorological variables with Bonferroni correction (see Table 2).

Table 2. Comparison of ACS by month adjusted for age, meteorological variables and sex
Reference Month Mean Difference (Reference-Month) 95% Confidence Interval for Difference Bonferroni corrected P value
Lower Upper
Month 1 2 58 -6.1 122.1 0.152
3 -188 -276.4 -99.6 < 0.001
4 -325 -428.1 -221.9 < 0.001
5 -87 -198.3 24.3 0.561
6 67 -29.3 163.3 1.000
7 66 -34.7 166.7 1.000
8 58 -44.8 160.8 1.000
9 65 -29.7 159.7 1.000
10 74 -6.0 154.0 0.122
11 54 -13.1 121.1 0.445
12 60 -3.3 123.3 0.092
Month 2 3 -246 -333.0 -159.0 < 0.001
4 -383 -477.9 -288.1 < 0.001
5 -145 -235.3 -54.7 < 0.001
6 9 -64.7 82.7 1.000
7 8 -70.2 86.2 1.000
8 0 -80.2 80.2 1.000
9 7 -65.9 79.9 1.000
10 16 -43.0 75.0 1.000
11 -4 -56.4 48.4 1.000
12 2 -47.8 51.8 1.000
Month 3 4 -137 -257.1 -16.9 0.008
5 101 -31.9 233.9 0.690
6 255 133.6 376.4 < 0.001
7 254 128.1 379.9 < 0.001
8 246 117.1 374.9 < 0.001
9 253 131.7 374.3 < 0.001
10 262 154.8 369.2 < 0.001
11 242 148.2 335.8 < 0.001
12 248 159.5 336.5 < 0.001
Month 4 5 238 116.7 359.3 < 0.001
6 392 281.4 502.6 < 0.001
7 391 277.9 504.1 < 0.001
8 383 269.9 496.1 < 0.001
9 390 281.9 498.1 < 0.001
10 399 299.9 498.1 < 0.001
11 379 282.8 475.2 < 0.001
12 385 290.1 479.9 < 0.001
Month 5 6 154 87.2 220.8 < 0.001
7 153 84.0 222.0 < 0.001
8 145 75.9 214.1 < 0.001
9 152 81.7 222.3 < 0.001
10 161 87.5 234.5 < 0.001
11 141 53.4 228.6 < 0.001
12 147 56.4 237.6 < 0.001
Month 6 7 -1 -50.8 48.8 1.000
8 -9 -59.5 41.5 1.000
9 -2 -52.2 48.2 1.000
10 7 -46.8 60.8 1.000
11 -13 -82.4 56.4 1.000
12 -7 -80.3 66.3 1.000
Month 7 8 -8 -58.8 42.8 1.000
9 -1 -51.5 49.5 1.000
10 8 -48.1 64.1 1.000
11 -12 -85.4 61.4 1.000
12 -6 -83.4 71.4 1.000
Month 8 9 7 -43.2 57.2 1.000
10 16 -39.9 71.9 1.000
11 -4 -79.5 71.5 1.000
12 2 -77.4 81.4 1.000
Month 9 10 9 -42.3 60.3 1.000
11 -11 -78.7 56.7 1.000
12 -5 -76.5 66.5 1.000
Month 10 11 -20 -76.1 36.1 1.000
12 -14 -72.0 44.0 1.000
Month 11 12 6 -44.8 56.8 1.000

General Linear Model performed.

Factors associated with ACS

Table 3 shows that the variables that were positively correlated with ACS events were wind speed (18 PM), daily evaporation, maximum and minimum relative humidity. Negatively correlated variables were daily relative humidity (6 PM). The analysis by gender shows that for men positive correlates were daily evaporation and daily maximum relative humidity, trend relationship with wind speed (18 PM). For women, wind speed (18 PM), daily minimum and maximum relative humidity were positive correlates; with daily relative humidity (18 PM) and minimum daily temperature negatively correlated with ACS events.

Table 3. Predictors for acute coronary syndrome
Variable IRR (95% CI) P value
All subjects
Male mean (SD): 6.13 (5.70) 1.03 (0.94 to 1.12) 0.598
Female mean (SD): 5.70 (5.10) 1.0
Age 1.001 (0.997 to 1.004) 0.749
Wind speed (18 PM) 1.051 (1.019 to 1.083) 0.001
Wind speed (12 MD) 0.982 (0.953 to 1.011) 0.220
Wind speed (6 AM) 1.009 (0.970 to 1.050) 0.653
Daily evaporation 1.039 (1.003 to 1.077) 0.032
Daily rain 0.992 (0.985 to 1.00) 0.060
Daily relative humidity (18 PM) 0.985 (0.978 to 0.992) < 0.001
Daily Relative humidity (12 MD) 0.998 (0.990 to 1.007) 0.683
Daily maximum relative humidity 1.036 (1.023 to 1.050) < 0.001
Daily minimum relative humidity 1.013 (1.004 to 1.022) 0.003
Maximum daily temperature 1.015 (0.997 to 1.034) 0.100
Minimum daily temperature 0.942 (0.927 to 0.958) < 0.001
Age 1.002 (0.997 to 1.007) 0.474
Wind speed (18PM) 1.039 (0.997 to 1.083) 0.067
Wind speed (12MD) 0.977 (0.937 to 1.020) 0.291
Wind speed (6AM) 1.015 (0.960 to 1.073) 0.612
Daily evaporation 1.056 (1.003 to 1.112) 0.039
Daily rain 0.991 (0.980 to 1.003) 0.133
Daily relative humidity (18PM) 0.990 (0.981 to 1.000) 0.060
Daily Relative humidity (12MD) 0.998 (0.987 to 1.010) 0.786
Daily maximum relative humidity 1.035 (1.016 to 1.054) < 0.001
Daily minimum relative humidity 1.009 (0.997 to 1.022) 0.144
Maximum daily temperature 1.011 (0.984 to 1.037) 0.430
Minimum daily temperature 0.945 (0.921 to 0.968) < 0.001
Age 0.999 (0.995 to 1.004) 0.756
Wind speed (18PM) 1.065 (1.019 to 1.114) 0.006
Wind speed (12MD) 0.986 (0.947 to 1.028) 0.508
Wind speed (6AM) 0.998 (0.944 to 1.050) 0.941
Daily evaporation 1.023 (0.975 to 1.055) 0.356
Daily rain 0.993 (0.983 to 1.004) 0.220
Daily relative humidity (18PM) 0.978 (0.968 to 0.988) < 0.001
Daily Relative humidity (12MD) 0.999 (0.987 to 1.011) 0.849
Daily maximum relative humidity 1.038 (1.020 to 1.057) < 0.001
Daily minimum relative humidity 1.017 (1.005 to 1.030) 0.006
Maximum daily temperature 1.021 (0.996 to 1.048) 0.106
Minimum daily temperature 0.939 (0.917 to 0.961) < 0.001

Negative Binomial regression performed.

Abbreviations: IRR, incident relative risk; CI, confidence interval.


The study aimed to evaluate the meteorological parameters and seasonal changes in relationship with incidence of ACS; as well as to identify gender differences. The results indicated that ACS admissions were higher March through May. Similarly March was reported as the month with the highest incidence of ACS in Germany.25 However, January was reported to have the highest incidence in the United Sates.17 Other studies found that the incidence and fatality risk of ACS were higher in the winter and spring.4,16,18,20,26-30 However, two additional studies reported that ACS was more common in summer.31,32 There are several mechanisms of climate changes that are suggested for the two pathological exogenous and endogenous responses. Lipid serum level, coagulation systems, and hormonal changes are among these features.23 Also, behavioral pattern variations following seasonal changes like changes in diet, physical activity, and psychosocial factors such as mood are considered as the emerging explanations for the high incidence of ACS in these seasons.33 Besides, variation in temperature,34 seasonal pattern occur such as infections like influenza epidemics,35 elevated concentration of fine element air pollution,10 seasonality phenomenon (i.e. winter depression, anxiety, sadness, social withdrawal, sleep disturbances, irritability, etc),10 respiratory tract infections,36 and reduction in the number of solar light hours37 are other proposed factors of the incidence of ACS. Therefore, differences in the patterns of ACS prevalence according to the time of year and changes in ambient climate within the same location may be reasonable explanations. This concept appears to be especially applicable to the regions of the world subjected to four distinct seasons and significantly different winter-to-summer weather conditions.38

The possible role of meteorological variables has been considered throughout the study. The present study confirmed the positive relationships between wind speed and the incidence of ACS. Goerre et al reported the same findings in their study in Switzerland.39 An inverse relationship was noted in the 10-year ecological study in Great Britain40 and a 12 years survey in Kaunas11 reported also negative correlations. However, another study failed to observe any significant relationships.23

It was investigated that relative humidity was among the factors that negatively correlated with the ACS incidences. Our findings concur with those by Abrignani et al,23 Messner et al,41 and Lee et al.42 one findings stated no correlations43 and two others reported positive relationships among these variables.44,45 Moreover, it seems that the presence of high air humidity may hinder swelling and also make it difficult the automatic processes of internal temperature control. Therefore, the respiratory fatigue and heart rate will be increased.23

Data on the role of environmental temperature are conflicting. One of the remarkable results of the present study was the negative association between daily minimum temperature and the hospital admission due to ACS; this suggests that the daily minimum temperature has a protective role in ACS. In other words, when the temperature is at lowest, it reduced ACS by 6 percent. Some studies indicated that the number of ACS are linked with the both colder and warmer temperatures.44,46,47 A 9-year survey (i.e. 2000-2009) in Hong Kong and Taiwan indicated that the lower mean temperature was associated with lower ACS risk on the same day.7 However, Kysely et al48 and Näyhä49 believe that fatality related to cold or heat is certainly not affected by hypo or hyperthermia. Also, Stewart et al reported that there is some evidence showing cold adaptation through longer exposure to the cold weather may occur. However, this approach is debatable.38 Also reduction in acute phase mortality, due to variations, such as earlier diagnosis of infarction, early and aggressive treatment, suitable reperfusion treatment, additional precise delineation of post ACS risk, as well as more suitable treatment of heart failure and mechanical complications after ACS are among the possible factors leading to reduction in morbidity and mortality following ACS.50,51 It also can be caused by indirect effects including cardiovascular disease that is exacerbated by physiological reactions of the man`s body aimed to adapt to the thermal environment.48,49 To the best of our knowledge, there is no study that reported a negative correlation between the minimum daily temperature and ACS incidence. Further research is needed to fully understand the individual conditions and cold exposure.

Given the fact that seasonal weather effects the prevalence, complications and outcomes of ACS, so that patients should modify their lifestyle particularly during the cold months with a diet rich in vitamins (e.g. vitamin D3), modifies activity level, suitable and warm clothes.52

Although the data of the current study have been extracted from the patients referred to the Sari, capital of Mazandaran city, our findings will be generalized to predict the occurrence of ACS in order to take preventive and therapeutic across the southern Caspian Sea. This happening can be due to the two causes; at first, weather characteristics as well as seasonal changes in the southern parts of the Caspian Sea follow relatively similar pattern53 and the next is that the residents of these areas are prone to vulnerability because of high population density.54


Similar to most studies, this study had several limitations: (1) the use of existing medical records that were collected for the purpose of diagnosis and treatment and not specifically for the purpose of this‏ research may not be ideal; (2) Over reporting, underreporting, and errors in reporting results in misclassification; (3) Lack of access to the details of all patient records (data including type of AMI, body mass index, blood pressure, past medical history, blood urea nitrogen, creatinine) precludes more detailed results; (4) On the other hand, a limitation of the present study was that we relied on central station monitoring for meteorological factors instead of measurements of exposure to environmental variables; (5) Usually in these hospitals, a wide range of patients with ACS and similar diseases are recorded in health information system. So we gathered all of them for the specified interval; (6) Another limitation to consider is that patients who died before reaching the hospital or patients that were not admitted to any hospital (outpatients) may have been excluded, thus underrepresenting the sample; (7) the possibility of having admitted patients from other provinces to this study could not be verified. Thus, caution must be exercised when interpreting the study results.

Nevertheless, several unique features of this study are the large sample size; we relied on central station monitoring for meteorological factors instead of measurements of exposure to environmental variables this provided us the dependent variables (meteorological data) data that was unbiased with regards to outcome of this study; and lastly using these data bases allowed us to answer research questions and generate new hypothesis for testing in future studies without the exorbitant cost of planning a prospective study.


We recommended that more detailed studies be conducted to verify the present results by other investigators. More detailed results about the incidence of ACS regarding to seasonal changes can help us in planning and thus potentially reducing ACS. Future studies with samples from different populations and also longitudinal designs are suggested to verify the findings of this study. Importantly, this study provides useful data that can be applied to future studies. Future studies are recommended that incorporate more detailed patients information (such as type of ACS, body mass index, blood pressure, past medical history, blood urea nitrogen, creatinine), wider climate areas (such as warm and dry; cold and dry).


Climate changes were found to be significantly associated with ACS. Especially from cold weather to hot weather in March, April and May. Therefore, emergency treatment service personnel should be more vigilant and fully prepared in March, April, and May for an increase in ACS patient admissions.

Ethical approval

The study was approved (Code: IR.MAZUMS.REC.96-10232) by the Ethics Committee of Mazandaran University of Medical Sciences, Sari, Iran, pursuant to its code of ethics, including assured confidentiality of all patient information.

Competing interests

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Authors’ contributions

HShN, YHC, RN, and AHG were on the management committee. HSHN, ESF, AHG, AKH, RP, and AY were on the scientific committee. RP, SPSh, HSHN, AKH, FA, and ESF were responsible for data interpretation and writing the report. RP, SPSh, and AKH did the statistical analysis. HShN, AHG, AY, RN, and RP were on the writing committee. HShN, AY, ESF, YHC, FA, AKH, and SPSh reviewed and revised the manuscript. All authors reviewed the manuscript.


This project was an inter-university collaboration and was supported by Mazandaran University of Medical Sciences, Taylor’s University and University of California San Francisco. We want to hereby extend our sincere gratitude to the all of the authorities of the heart center who helped to make this research possible.


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Submitted: 03 Aug 2018
Revised: 02 Feb 2019
Accepted: 10 Feb 2019
First published online: 25 May 2019
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