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Experimental investigation of the effects of acute exercise on memory interference

Health Promotion Perspectives, 8(3), 208-214; DOI:10.15171/hpp.2018.28

Original Article

Experimental investigation of the effects of acute exercise on memory interference

Savanna Wingate1, Lindsay Crawford1, Emily Frith1, Paul D. Loprinzi1 ,*

1 Exercise Psychology Laboratory, Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, USA

Email: pdloprin@olemiss.edu

© 2018 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Among other factors, including the decay theory, interfering stimuli (proactive and retroactive interference; PI and RI) may influence the encoding and consolidation of target information. Acute exercise can enhance episodic memory function, but no experiments have evaluated whether exercise can attenuate PI and RI effects on memory, which was the purpose of this experiment.Methods: Twenty young adults were randomized (via computer program) into one of 6 experimental groups (N=120, n=20 per group), including 3 PI (G1, G2, and G3) and 3 RIgroups (G4, G5, and G6). Those in G1 and G4 exercised prior to a 10-list AB/AC paradigm with interference; G2 and G5 did not exercise but had interference; and G3 and G6 were the control groups with no exercise and no interference.Results: The mean (95% CI) number of correctly recalled word pairs across the 6 respective groups was 2.4 (1.2-3.5), 2.4 (1.3-3.5), 5.1 (3.9-6.3), 6.9 (5.7-8.0), 5.0 (4.2-5.8), and 6.1 (5.1-6.9) (FANOVA=11.7; P<0.001; η2=0.33). For PI, the control group (group 3) correctly recalled more word pairs (5.1) when compared to the exercise interference group (2.4; group 1) or the non-exercise interference group (2.4; group 2). The difference between group 1 and 3 (2.4 vs.5.1) was significant (P=0.003), as was group 2 vs. 3 (P=0.002). For the RI groups (groups 4-6),group 4 differed from group 5 (6.9 vs. 5.0; P=0.01), but there was no difference between group 4 and group 6 (P=0.25) or group 5 and group 6 (P=0.09).Conclusion: These preliminary findings suggest that acute exercise may be more beneficial for RI compared to PI, but additional experimental work is needed.

Keywords: Acquisition, Consolidation, Encoding, Memory, Physical activity

Citation: Wingate S, Crawford L, Frith E, Loprinzi PD. Experimental investigation of the effects of acute exercise on memory interference.Health Promot Perspect. 2018;8(3):208-214. doi: 10.15171/hpp.2018.28.

Introduction

The durability of an episodic memory depends on the extent to which the event was encoded as well as factors occurring during the consolidation of the memory. For example, instability of the memory may result from the biological substrate encoding the engram to disintegrate or decay with time; the learned information may be processed in a way that results in erasing of part of the engram; other information may alter the engram or interfere with its expression; critical retrieval cues may fail to be employed; and/or employing inappropriate processing during memory retrieval may influence memory recall.1

Among other factors, including the decay theory,2 interfering stimuli may influence the encoding and consolidation of target information. Proactive interference occurs when the competing stimuli precedes the target information to be learned, whereas retroactive interference (RI) occurs when the competing stimuli comes after the material to be learned. The standard paradigm for assessing memory interference is the AB/AC paradigm, which suggests that memory is worse for associations (AB trials) when one member of the association is shared in a subsequent trial (AC trials) then for associations where a member is not subsequently represented (DE trials). Mechanisms of this effect may include item suppression, candidate competition and associative competition effects. Emerging work demonstrates that memory reactivation, or the reinstatement of processes and representations engaged when an event is initially experienced, may help increase resistance to RI.3 Although speculative, this may occur by providing an opportunity to re-encode and thus strengthen the association between the word and its original encoding task.3 Additionally, emerging work demonstrates that the medial prefrontal cortex plays a critical role in minimizing interference effects by helping to discriminate among conflicting representations.4

Recent work demonstrates that acute exercise engagement may help to facilitate episodic memory function.5-10 Specifically, exercise prior to the memory encoding may help to facilitate CREB-1 levels11 as well as neuronal excitability,12,13 thus helping to prime neuronal cells into encoding a particular memory.14 Additionally, enhanced attention may facilitate memory encoding via modulation of the dopamine neurotransmitter acting on D1/D5 receptors,15 with animal work showing that exercise can increase the expression of dopamine and dopamine receptors,16,17 possibly through DA-D2R protein expression.18,19 Additionally, exercise has been shown to upregulate AMPA receptor levels,20,21 open NMDA channels,22 phosphorylate glutamate receptors, and increase EPSP in the hippocampus,20 which are key characteristics of facilitating memory-related long-term potentiation.23

What has yet to be investigated is whether acute exercise can minimize a memory interference effect, as assessed via the AB/AC paradigm. Such an effect is plausible given the observed effect that acute exercise has on post-exercise neuronal activity in the prefrontal cortex,24 coupled with the effect the prefrontal cortex plays in minimizing a memory interference effect.4 Thus, the purpose of this study was to examine whether acute moderate-intensity exercise can reduce proactive- and retroactive-memory interference. We hypothesize that, compared to a non-exercise memory interference group, a short bout of acute moderate-intensity exercise will reduce proactive- and retroactive-memory interference, and thus, enhance short-term associative memory. This may have important health promotion implications as memory function is vital for optimal daily functioning.25

Materials and Methods

Study design

All data collection occurred between August and December of 2017, with all data collection occurring in the authors’ Exercise Psychology Laboratory. The present study is a 6-arm, parallel, between-group randomized controlled trial. Randomization was employed using a computer-generated program. See Table 1 for an overview of the study design and for how proactive and retroactive interference was assessed. For proactive interference, three groups were assessed (groups 1-3), including 2 experimental arms and a control arm. Experimental arm 1 involved exercising prior to the AB/AC paradigm; experimental arm 2 involved no exercise prior to the AB/AC paradigm; and the control arm involved no interference effect, i.e., learning AC and then recalling AC. Groups 4-6 were identical to groups 1-3 except RI was assessed (Table 1).

Table 1. Study design to assess proactive and retroactive interference
Group No. Group Classification Proactive Interference
Learn List 1 Learn List 2 Cued-Recall List 2
1 Experimental 1 – Exercise A-B A-C A-C
2 Experimental 2 – No Exercise A-B A-C A-C
3 Control – No Exercise A-C A-C
Retroactive Interference
Learn List 1 Cued-Recall List 2
4 Experimental 1 – Exercise A-B A-C A-B
5 Experimental 2 – No Exercise A-B A-C A-B
6 Control – No Exercise A-B A-B
Six independent groups for this experiment (N = 120).
Experimental arm 1 involves exercising prior to learning List 1; Experimental arm 2 involves no exercise prior to learning List 1; Control arm involves no interference effect. The same design occurs for experimental arms 4-6.

The exercising groups (groups 1 and 4; Table 1) consisted of engaging in an acute 15-minute bout of moderate-intensity exercise, resting for 5 minutes in a seated position, and then completed the AB/AC paradigm. The remaining groups sat quietly for 20 minutes and then completed the AB/AC paradigm. Additional details to follow.

Participants

Each group included approximately 20 participants (college students), which aligns with our other related experimental work.6-10 With 6 groups total, the total sample size included 120 participants. Participants were recruited through classroom announcements and word-of-mouth. Participants included male and females from the ages of 18 to 35 years. Additionally, participants were excluded if they self-reported as a daily smoker,26,27 self-reported being pregnant,28 exercised within 5 hours of testing,5 consumed caffeine within 3 hours of testing,29 had a concussion or head trauma within the past 30 days,30 took marijuana or other illegal drugs within the past 30 days,31 were considered a “heavy” alcohol user (>30 drinks/month for women; >60 drinks/month for men),32 or were left-hand dominant or mixed-handed.33

Exercise protocol

Those randomized to the exercise group walked on a treadmill for 15 minutes at a self-selected “brisk walking” pace. Specifically, they were told to “self-select a brisk walking pace, a pace as if you were late for class; please ensure that the speed is at least 3.0 mph and maintain this speed throughout the treadmill walk.” The researcher confirmed that the speed was maintained throughout the exercise bout. This exercise has previously been shown to enhance episodic memory.34

Memory assessment

Procedures of this employed AB/AC paradigm are described elsewhere.35 Randomly selected word pairs from the Toronto Word Pool were used. In the initial study trial (List 1), 10 pairs were presented one at a time on a computer screen for 5-seconds each. Three cycles of this occurred. Immediately after viewing List 1 for the third cycle, participants began the second list, using the same procedure as described for List 1 (see Table 2 for word pairs that were used for List 1 and List 2). After studying List 2, participants performed a distractor task for 5 minutes. This involved watching a 5-minute video clip of the TV show “The Office” and then rating the humor level of this clip.

Table 2. Paired word lists
List 1: A-B List List 2: A-C List
A B A C
Belief Mother Belief Legend
Ticket Hero Ticket Duty
Penny Pursuit Penny Patience
Endure Wrinkle Endure Liquid
Wander Against Wander Pupil
Sincere Funny Sincere Belong
Invent Survive Invent Former
Rapid Column Rapid Discuss
Series Pillow Series Because
Fever Hammer Fever Noble

Immediately after this distractor task, participants performed a cued-recall assessment. As noted in Table 1, groups 1-3 were asked to perform a cued-recall of List 2, whereas groups 4-6 were asked to perform a cued-recall of List 1. The cued-recall involved one of the first words from a randomly selected pair from the appropriate list being presented on a computer screen for 20 seconds. The participant then wrote down the second word from that pair in a booklet. This continued until all 10 pairs were completed.

The outcome of interest was the number of correctly recalled pairs (max score is 10). For the proactive interference procedures (Table 1), we anticipated that the control scenario (group 3) would have the highest score. We then anticipated that, among the 2 proactive interference experimental arms (groups 1 and 2), those who exercised prior to List 1 (group 1) would have a reduced proactive interference effect when compared to group 2, and thus, group 1 would correctly recall more pairs than group 2. We anticipated the same trend for retroactive interference.

Physical activity assessment

Habitual self-reported moderate-to-vigorous physical activity (MVPA) assessment36 was measured using the Physical Activity Vital Sign instrument. Participants self-reported the number of minutes per week engaged in MVPA. This assessment has demonstrated evidence of validity.37-41 Notably, this self-report MVPA measure correlates with accelerometer-assessed number of days > 30 bout-min MVPA (r = 0.52, P < 0.001).38

Mood assessment

A mood state survey (PANAS) was used to assess overall mood state.42 Regarding the Positive and Negative Affect Schedule (PANAS),42 participants rated 20 items (e.g., excited, upset, irritable, attentive) on a Likert scale (1, very slightly or not at all; to 5, extremely), with half of the items constituting a “positive” mood state, with the other half being a “negative” mood state. In this sample, for the positive and negative mood states, respectively, Cronbach’s alpha was 0.90 and 0.82. For potential confounding purposes, we assessed these variables (physical activity and mood) to determine the similarities of these parameters across the 6 experimental groups.

Statistical analysis

All analyses were computed in SPSS (v. 22, IBM SPSS, Armonk, NY, USA). An analysis of variance (ANOVA) test was computed to examine cued-recall scores across the groups, with Bonferroni post hoc tests employed. All assumptions (independence of cases, normality and equality of variances) of this analytical test were assessed and determined not to be violated. Statistical significance was established as a nominal alpha of 0.05.

Results

Characteristics of the sample, across the 6 experimental groups, are shown in Table 3. Participants were similar across the demographic, behavioral, physiological (resting heart rate), and psychological assessments (mood state). The 2 exercise groups had a similar exercise-induced physiological response (exercise heart rate).

Table 3. Characteristics of the sample across the 6 groups
Variable Group 1 Group 2 Group 3 Group 4 Group 5 Group 6
Number 20 21 20 19 20 20
Age (y), mean 19.9 (0.3) 21.0 (0.3) 20.7 (0.3) 20.7 (0.6) 20.8 (0.2) 20.4 (0.3)
Men, % 10.0 23.8 30.0 15.8 30.0 40.0
White, % 70.0 66.6 80.0 73.6 75.0 55.0
Waist circumference, mean cm 83.5 (2.7) 82.2 (2.1) 81.9 (3.0) 78.6 (4.0) 85.0 (3.4) 85.3 (2.3)
MVPA, mean min/wk 241.5 (38.4) 187.8 (35.4) 199.2 (35.8) 250.0 (48.7) 148.7 (27.4) 244.0 (48.7)
Mood, mean positive 30.2 (2.1) 27.2 (1.7) 30.6 (1.7) 29.9 (2.3) 29.6 (2.0) 30.2 (1.9)
Mood, mean negative 12.1 (0.7) 12.6 (0.8) 11.7 (0.4) 13.3 (0.9) 15.9 (1.3) 14.3 (1.0)
Resting HR, bpm 82.3 (2.2) 77.0 (3.2) 76.5 (2.5) 76.6 (3.7) 77.9 (2.7) 79.7 (2.4)
End of Exercise HR, bpm 115.9 (5.7) - - 112.8 (5.8) - -
Memory Recall, mean No. of correctly recalled word pairs 2.4 (0.6) 2.4 (0.5) 5.1 (0.6) 6.9 (0.5) 5.0 (0.4) 6.1 (0.4)
Abbreviations: MVPA, moderate-to-vigorous physical activity, HR, heart rate; BPM, beats per minute.
Participants randomized into one of 6 experimental groups (N=120), including 3 Prospective Interference (G1, G2, and G3) and 3 Retrospective Interference groups (G4, G5, and G6). Those in G1 and G4 exercised prior to the AB/AC paradigm with interference; G2 and G5 did not exercise but had interference; and G3 and G6 were the control groups with no exercise and no interference.
Variance estimates in parentheses are standard error values.

Figure 1 displays the mean number of correctly recalled word pairs across the 6 experimental groups (numeric values also shown in Table 3). The mean (95% CI) number of correctly recalled word pairs across the 6 respective groups was 2.4 (1.2-3.5), 2.4 (1.3-3.5), 5.1 (3.9-6.3), 6.9 (5.7-8.0), 5.0 (4.2-5.8), and 6.1 (5.1-6.9) (FANOVA=11.7; P < 0.001; η2= 0.33). As expected, for proactive interference the control group (group 3) correctly recalled more word pairs (5.1) when compared to the exercise interference group (2.4; group 1) or the non-exercise interference group (2.4; group 2). The difference between Group 1 and 3 (2.4 vs. 5.1) was statistically significant (P = 0.003), as was group 2 vs. 3 (P = 0.002). For the retroactive interference groups (groups 4-6), group 4 statistically differed from group 5 (6.9 vs. 5.0; P = 0.01), but there was no statistical difference between group 4 and group 6 (P = 0.25) or group 5 and group 6 (P = 0.09).

Figure 1. Number of correctly recalled word pairs across the 6 experimental groups.

Discussion

The purpose of this experiment was to examine the effects of acute exercise on episodic memory function while manipulating a potential interference effect. The motivation for this experiment was 2-fold: (1) interfering stimuli (PI or RI) can influence memory retrieval, and (2) acute exercise has been shown to improve episodic memory function without competing stimuli. In this experiment, we were able to induce a proactive interference effect, as demonstrated by group 3 correctly recalling more word pairs than groups 1 and 2. Acute exercise did not minimize a proactive interference effect, as groups 1 and 2 correctly recalled a similar number of words (2.4). Regarding retroactive interference, group 6 (6.1) correctly recalled more words than group 5 (5.0), suggesting that a retroactive interference effect was observed. However, this difference was not statistically significant, suggesting that this retroactive interference effect was not completely observed. Relying on statistical significance, however, is a questionable practice.43-45 Interestingly, group 4 correctly recalled more words than group 5 (6.9 vs. 5.0), providing some suggestive evidence that acute exercise may help to minimize a retroactive interference effect. Until future confirmatory work is completed, such a possibility, however, should be interpreted cautiously.

Although not in the context of a cognitive-related episodic memory task, recently, Lauber et al46 evaluated whether a single session of high-intensity interval training (HIIT) can mitigate the effects of an interfering motor task. Participants performed ballistic training and then the HIIT either before or after practicing an interfering accuracy motor task. After ballistic training, all groups increased their performance in the trained and untrained limb. However, despite practicing the interfering task, the HIIT bout before the interfering task maintained their ballistic performance, whereas the group that engaged in HIIT after the interfering task showed an interference effect. This suggests that exercise prior to an interference task may help to minimize a motor memory interference effect. The findings of our experiment did not demonstrate evidence that acute moderate-intensity exercise can reduce a proactive interference effect, but our findings provide some support that acute exercise may be useful in mitigating a retroactive interference effect. Compared to those who did not exercise (group 5), those who exercised (group 4) before the training list (List 1) had a greater cued-recall on List 1 even after being exposed to List 2 prior to the recall. This observation aligns with other work demonstrating that acute exercise can improve working memory performance,47-51 which has a similar temporal protocol (i.e., exposed to a target item, then exposed to a competing stimulus, and then recall the target item) to that of our retroactive interference protocol.

Acute exercise may help to minimize a retroactive interference effect by enhancing markers of working memory (e.g., BDNF, post-synaptic density protein 9552). Catecholamines, such as dopamine and norepinephrine play a critical role in working memory capacity.53 For example, D1 receptor stimulation enhances the excitability of prefrontal pyramidal cells and potentiates glutamate gated currents.53 Importantly, working memory is optimized at intermediate levels of D1 receptor stimulation and is degraded by either too little, or too much activation of this dopamine receptor.53 Given the exercise-induced effects on dopamine production,17 moderate-intensity exercise, in particular, may help to optimize changes in these molecular mediators of working memory capacity. Additionally, psychological models have been developed as a potential mechanistic explanation for individual differences in working memory capacity. Relatedly, cognitive attention plays a critical role in working memory capacity,53 and in theory, moderate-intensity exercise intensity may have an optimal effect on attention-influenced working memory capacity.9

In conclusion, our findings provide some suggestive evidence that acute exercise may, partially, minimize a retroactive interference effect. Future confirmatory work is needed, and if confirmed, mechanistic work will be needed to identify why exercise may help to minimize retroactive interference but not influence proactive interference. Despite the strengths of this study, which includes its novelty, comprehensiveness, and experimental design approach, future work should overcome the limitations of this study. A limitation includes the relatively small sample size per group. Additionally, future work should consider a within-subject design. The major source of outcome variance in between-subject designs is individual differences among the participants, and a within-subject design may help to minimize this outcome heterogeneity and potentially maximize exercise-induced effects. Such a within-subject design should consider other techniques to evaluate proactive and retroactive interference, such as using Yule’s Q for associative interference.54,55 If such future replicative work provides robust evidence that exercise can minimize a memory interference effect, then this may have important health promotion implications, as memory function is vital for optimal daily functioning.25

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the University of Mississippi institutional review board (#18-001), with informed consent obtained from all individual participants included in the study.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SW and LC collected the data. PL performed analyses and drafted the manuscript. All authors have reviewed and provided intellectual feedback on the manuscript. All authors have read and approved the final version of the manuscript and agree with the order of presentation of the authors.

References

  1. Dudai Y. Memory: from A to Z. Oxford: Oxford University Press; 2004. p. 100-1.
  2. Ricker TJ, Vergauwe E, Cowan N. Decay theory of immediate memory: From Brown (1958) to today (2014). Q J Exp Psychol (Hove) 2016;69(10):1969-95. doi: 10.1080/17470218.2014.914546. [Crossref]
  3. Koen JD, Rugg MD. Memory reactivation predicts resistance to retroactive interference: evidence from multivariate classification and pattern similarity analyses. J Neurosci 2016;36(15):4389-99. doi: 10.1523/jneurosci.4099-15.2016. [Crossref]
  4. Guise KG, Shapiro ML. Medial prefrontal cortex reduces memory interference by modifying hippocampal encoding. Neuron 2017;94(1):183-92.e8. doi: 10.1016/j.neuron.2017.03.011. [Crossref]
  5. Labban JD, Etnier JL. Effects of acute exercise on long-term memory. Res Q Exerc Sport 2011;82(4):712-21. doi: 10.1080/02701367.2011.10599808. [Crossref]
  6. Crush EA, Loprinzi PD. Dose-response effects of exercise duration and recovery on cognitive functioning. Percept Mot Skills 2017;124(6):1164-93. doi: 10.1177/0031512517726920. [Crossref]
  7. Frith E, Sng E, Loprinzi PD. Randomized controlled trial evaluating the temporal effects of high-intensity exercise on learning, short-term and long-term memory, and prospective memory. Eur J Neurosci 2017;46(10):2557-64. doi: 10.1111/ejn.13719. [Crossref]
  8. Jaffery A, Edwards MK, Loprinzi PD. The effects of acute exercise on cognitive function: solomon experimental design. J Prim Prev 2018;39(1):37-46. doi: 10.1007/s10935-017-0498-z. [Crossref]
  9. Loprinzi PD, Kane CJ. Exercise and cognitive function: a randomized controlled trial examining acute exercise and free-living physical activity and sedentary effects. Mayo Clin Proc 2015;90(4):450-60. doi: 10.1016/j.mayocp.2014.12.023. [Crossref]
  10. Loprinzi PD, Frith E, Edwards MK, Sng E, Ashpole N. The effects of exercise on memory function among young to middle-aged adults: systematic review and recommendations for future research. Am J Health Promot 2018;32(3):691-704. doi: 10.1177/0890117117737409. [Crossref]
  11. Chen MJ, Russo-Neustadt AA. Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent. Hippocampus 2009;19(10):962-72. doi: 10.1002/hipo.20579. [Crossref]
  12. Cunha C, Brambilla R, Thomas KL. A simple role for BDNF in learning and memory? Front Mol Neurosci 2010;3:1. doi: 10.3389/neuro.02.001.2010. [Crossref]
  13. Zoladz JA, Pilc A. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 2010;61(5):533-41.
  14. Loprinzi PD, Edwards MK, Frith E. Potential avenues for exercise to activate episodic memory-related pathways: a narrative review. Eur J Neurosci 2017;46(5):2067-77. doi: 10.1111/ejn.13644. [Crossref]
  15. Muzzio IA, Kentros C, Kandel E. What is remembered? Role of attention on the encoding and retrieval of hippocampal representations. J Physiol 2009;587(Pt 12):2837-54. doi: 10.1113/jphysiol.2009.172445. [Crossref]
  16. Vuckovic MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, et al. Exercise elevates dopamine D2 receptor in a mouse model of Parkinson’s disease: in vivo imaging with [(1)(8)F]fallypride. Mov Disord 2010;25(16):2777-84. doi: 10.1002/mds.23407. [Crossref]
  17. Lin TW, Kuo YM. Exercise benefits brain function: the monoamine connection. Brain Sci 2013;3(1):39-53. doi: 10.3390/brainsci3010039. [Crossref]
  18. Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK, et al. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res 2004;77(3):378-90. doi: 10.1002/jnr.20162. [Crossref]
  19. Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 2011;63(1):182-217. doi: 10.1124/pr.110.002642. [Crossref]
  20. VanLeeuwen JE, Petzinger GM, Walsh JP, Akopian GK, Vuckovic M, Jakowec MW. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Res 2010;88(3):650-68. doi: 10.1002/jnr.22216. [Crossref]
  21. Real CC, Ferreira AF, Hernandes MS, Britto LR, Pires RS. Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain. Brain Res 2010;1363:63-71. doi: 10.1016/j.brainres.2010.09.060. [Crossref]
  22. Yu Q, Li X, Wang J, Li Y. Effect of exercise training on long-term potentiation and NMDA receptor channels in rats with cerebral infarction. Exp Ther Med 2013;6(6):1431-6. doi: 10.3892/etm.2013.1319. [Crossref]
  23. Lynch MA. Long-term potentiation and memory. Physiol Rev 2004;84(1):87-136. doi: 10.1152/physrev.00014.2003. [Crossref]
  24. Endo K, Matsukawa K, Liang N, Nakatsuka C, Tsuchimochi H, Okamura H, et al. Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation. J Physiol Sci 2013;63(4):287-98. doi: 10.1007/s12576-013-0267-6. [Crossref]
  25. Tomaszewski Farias S, Cahn-Weiner DA, Harvey DJ, Reed BR, Mungas D, Kramer JH, et al. Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clin Neuropsychol 2009;23(3):446-61. doi: 10.1080/13854040802360558. [Crossref]
  26. Jubelt LE, Barr RS, Goff DC, Logvinenko T, Weiss AP, Evins AE. Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia. Psychopharmacology (Berl) 2008;199(1):89-98. doi: 10.1007/s00213-008-1133-8. [Crossref]
  27. Klaming R, Annese J, Veltman DJ, Comijs HC. Episodic memory function is affected by lifestyle factors: a 14-year follow-up study in an elderly population. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2017;24(5):528-42. doi: 10.1080/13825585.2016.1226746. [Crossref]
  28. Henry JD, Rendell PG. A review of the impact of pregnancy on memory function. J Clin Exp Neuropsychol 2007;29(8):793-803. doi: 10.1080/13803390701612209. [Crossref]
  29. Sherman SM, Buckley TP, Baena E, Ryan L. Caffeine Enhances memory performance in young adults during their non-optimal time of day. Front Psychol 2016;7:1764. doi: 10.3389/fpsyg.2016.01764. [Crossref]
  30. Wammes JD, Good TJ, Fernandes MA. Autobiographical and episodic memory deficits in mild traumatic brain injury. Brain Cogn 2017;111:112-26. doi: 10.1016/j.bandc.2016.11.004. [Crossref]
  31. Hindocha C, Freeman TP, Xia JX, Shaban NDC, Curran HV. Acute memory and psychotomimetic effects of cannabis and tobacco both ‘joint’ and individually: a placebo-controlled trial. Psychol Med 2017;47(15):2708-19. doi: 10.1017/s0033291717001222. [Crossref]
  32. Le Berre AP, Fama R, Sullivan EV. Executive functions, memory, and social cognitive deficits and recovery in chronic alcoholism: a critical review to inform future research. Alcohol Clin Exp Res 2017;41(8):1432-43. doi: 10.1111/acer.13431. [Crossref]
  33. Alipour A, Aerab-sheybani K, Akhondy N. Effects of handedness and depth of processing on the explicit and implicit memory. Procedia Soc Behav Sci 2012;32:29-33. doi: 10.1016/j.sbspro.2012.01.005. [Crossref]
  34. Sng E, Frith E, Loprinzi PD. Temporal effects of acute walking exercise on learning and memory function. Am J Health Promot. 2017:890117117749476. doi: 10.1177/0890117117749476. [Crossref]
  35. Bower GH, Thompson-Schill S, Tulving E. Reducing retroactive interference: an interference analysis. J Exp Psychol Learn Mem Cogn 1994;20(1):51-66.
  36. Greenwood JL, Joy EA, Stanford JB. The Physical Activity Vital Sign: a primary care tool to guide counseling for obesity. J Phys Act Health 2010;7(5):571-6.
  37. Ball TJ, Joy EA, Goh TL, Hannon JC, Gren LH, Shaw JM. Validity of two brief primary care physical activity questionnaires with accelerometry in clinic staff. Prim Health Care Res Dev 2015;16(1):100-8.
  38. Ball TJ, Joy EA, Goh TL, Hannon JC, Gren LH, Shaw JM. Validity of two brief primary care physical activity questionnaires with accelerometry in clinic staff. Prim Health Care Res Dev 2015;16(1):100-8. doi: 10.1017/s1463423613000479. [Crossref]
  39. Ball TJ, Joy EA, Gren LH, Cunningham R, Shaw JM. Predictive validity of an adult physical activity “vital sign” recorded in electronic health records. J Phys Act Health 2016;13(4):403-8. doi: 10.1123/jpah.2015-0210. [Crossref]
  40. Ball TJ, Joy EA, Gren LH, Shaw JM. Concurrent validity of a self-reported physical activity “vital sign” questionnaire with adult primary care patients. Prev Chronic Dis 2016;13:E16. doi: 10.5888/pcd13.150228. [Crossref]
  41. Fowles JR, O’Brien MW, Wojcik WR, d’Entremont L, Shields CA. A pilot study: Validity and reliability of the CSEP-PATH PASB-Q and a new leisure time physical activity questionnaire to assess physical activity and sedentary behaviours. Appl Physiol Nutr Metab 2017;42(6):677-80. doi: 10.1139/apnm-2016-0412. [Crossref]
  42. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988;54(6):1063-70.
  43. Cumming G. The new statistics: why and how. Psychol Sci 2014;25(1):7-29. doi: 10.1177/0956797613504966. [Crossref]
  44. The B. Significance testing - are we ready yet to abandon its use? Curr Med Res Opin 2011;27(11):2087-90. doi: 10.1185/03007995.2011.618493. [Crossref]
  45. Wasserstein RL, Lazar NA. The ASA’s statement on p-values: context, process, and purpose. Am Stat 2016;70(2):129-33. doi: 10.1080/00031305.2016.1154108. [Crossref]
  46. Lauber B, Franke S, Taube W, Gollhofer A. The effects of a single bout of exercise on motor memory interference in the trained and untrained hemisphere. Neuroscience 2017;347:57-64. doi: 10.1016/j.neuroscience.2017.01.048. [Crossref]
  47. Hwang J, Castelli DM, Gonzalez-Lima F. Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise. Lasers Med Sci 2016;31(6):1151-60. doi: 10.1007/s10103-016-1962-3. [Crossref]
  48. Weng TB, Pierce GL, Darling WG, Voss MW. Differential effects of acute exercise on distinct aspects of executive function. Med Sci Sports Exerc 2015;47(7):1460-9. doi: 10.1249/mss.0000000000000542. [Crossref]
  49. Hogan CL, Mata J, Carstensen LL. Exercise holds immediate benefits for affect and cognition in younger and older adults. Psychol Aging 2013;28(2):587-94. doi: 10.1037/a0032634. [Crossref]
  50. Tsujii T, Komatsu K, Sakatani K. Acute effects of physical exercise on prefrontal cortex activity in older adults: a functional near-infrared spectroscopy study. Adv Exp Med Biol 2013;765:293-8. doi: 10.1007/978-1-4614-4989-8_41. [Crossref]
  51. Li L, Men WW, Chang YK, Fan MX, Ji L, Wei GX. Acute aerobic exercise increases cortical activity during working memory: a functional MRI study in female college students. PLoS One 2014;9(6):e99222. doi: 10.1371/journal.pone.0099222. [Crossref]
  52. Shih PC, Yang YR, Wang RY. Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PLoS One 2013;8(10):e78163. doi: 10.1371/journal.pone.0078163. [Crossref]
  53. Khan ZU, Muly EC. Molecular mechanisms of working memory. Behav Brain Res 2011;219(2):329-41. doi: 10.1016/j.bbr.2010.12.039. [Crossref]
  54. Kahana MJ. Associative symmetry and memory theory. Mem Cognit 2002;30(6):823-40. doi: 10.3758/bf03195769. [Crossref]
  55. Warrens MJ. On association coefficients for 2x2 tables and properties that do not depend on the marginal distributions. Psychometrika 2008;73(4):777-89. doi: 10.1007/s11336-008-9070-3. [Crossref]

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Article History

Submitted: 25 Feb 2018
Revised: 16 May 2018
Accepted: 19 May 2018
First published online: 07 Jul 2018

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