Neda Roshanravan
1,2 
, Helda Tutunchi
3, Rezayat Parvizi
2, Sepideh Bastani
4, Mohammad Asghari Jafarabadi
5,6,7,8, Elnaz Faramarzi
9, Naimeh Mesri Alamdari
3 , Zohreh Ghoreishy
10, Faezeh Tarighat
11, Kazem Mehravani
2, Milad Vahedinezhad
12, Nazli Namazi
13* , Samad Ghaffari
2* 1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
5 Cabrini Research, Cabrini Health, Malvern, VIC, 3144, Australia
6 School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia
7 Department of Psychiatry, School of Clinical Sciences, Monash University, Clayton, VIC, 3168, Australia
8 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
9 Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
10 Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
11 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
12 Rajaie Cardiovascular Medical and Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
13 Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background: Atherosclerotic cardiovascular disease (ASCVD) is considered a worldwide health problem associated with high morbidity, mortality, and cost of care. In the present study, we examined risk-enhancing factors for ASCVD in healthcare workers of the AZAR cohort population.
Methods: Data from a total of 500 participants were used for this cross-sectional study. Demographic characteristics, anthropometric indices, biochemical factors, and blood pressure were assessed. To evaluate the associations of ASCVD with the parameters mentioned above, univariate and multivariate logistic regression analyses were conducted.
Results: The total frequency of subjects with severe (≥7.5) and low (<7.5) ASCVD was 7.6% (95% CI: 5.4-10.3), and 90.6% (95% CI: 87.7-93.0), respectively. The top strongest links were found between ASCVD and atherogenic index of plasma (AIP) (odds ratio [OR]: 12.8, 95% CI: 3.2-49.9), diabetes (OR: 7.6, 95% CI: 2.8-25), and daily smoking (OR: 7.0, 95% CI: 2.8-20). Based on a multivariate logistic regression model, low-density lipoprotein cholesterol (LDL-C)/apolipoprotein B (Apo b), diabetes, hematocrit, age, Triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C), systolic blood pressure, HDL-C, apolipoprotein A-I (Apo A-I), hemoglobin, and Apo B/Apo A-I have significant associations with ASCVD severity.
Conclusion: In conclusion, the present study showed significant associations between the severity of ASCVD with some parameters among healthcare workers of AZAR cohort study.