2022: Two-year Impact Factor: 4.4
Scopus Journal Metrics
CiteScore (2022): 5.3
SJR(2022): 0.78
Open Access

Health Promot Perspect. 2022;12(2): 212-217.
doi: 10.34172/hpp.2022.26
PMID: 36276415
PMCID: PMC9508391
Scopus ID: 85147800697
  Abstract View: 414
  PDF Download: 302
  Full Text View: 45

Original Article

What hematological and endocrinal indicators are important in COVID-19 infection?

Alireza Ostadrahimi 1 ORCID logo, Vahideh Sadra 2 ORCID logo, Amir Bahrami 2 ORCID logo, Zohreh Razzaghi 2, Mostafa Najafipour 3 ORCID logo, Helda Tutunchi 2 ORCID logo, Farzad Najafipour 2* ORCID logo

1 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2 Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Internal Medicine, Faculty of Medicine, Ardabil Azad University of Medical Sciences, Ardabil, Iran
*Corresponding Author: Corresponding Author: Farzad Najafipour, Email: , Email: Farzadnajafipour@gmail.com


Background: Clinical evidence of endocrine involvement in coronavirus disease needs further investigation. The aim of the present study was to assess the relationship between hematology and endocrine parameters in coronavirus disease 2019 (COVID-19) infection.

Methods: In the present cross-sectional study, a total of 320 patients (215 survivors and 105 non-survivors) with confirmed COVID-19 infection were enrolled. After isolation of serum samples, hematological, biochemical, and hormonal parameters were analyzed.

Results: The mean age of survivors and non-survivors was 58.92 (SD: 15.28) and 63.65 (SD: 16.62) years, respectively. The results demonstrated significant differences in free triiodothyronine (FT3) [MD (95% CI): 0.40 (0.10, 0.71), P=0.009], total calcium [MD (95% CI): 0.53 (0.21, 0.86), P=0.003], vitamin D [MD (95% CI): 7.72 (6.38, 9.05), P=0.003], erythrocyte sedimentation rate (ESR) [MD (95% CI): 17.09 (9.38, 22.05), P=0.004) and serum ferritin [Median difference: -1091.9, P<0.001), between survivors and non-survivors, respectively.

Conclusion: The results revealed that some hematological and endocrine factors play an important role in prognosis of COVID-19 infection. However, further studies with a larger population are required to clarify the exact effects of COVID-19 on the endocrine system.

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Submitted: 16 Apr 2022
Accepted: 10 May 2022
ePublished: 20 Aug 2022
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