The acceptance of the coronavirus disease 2019 (COVID-19) vaccine has been described as a gateway to attaining herd immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The critical role of community participation (CP) has been successfully demonstrated in previous vaccination programs globally. This perspective therefore aimed to describe how CP could be used to promote COVID-19 vaccination acceptance. To promote COVID-19 vaccine acceptance, it is required that a mapping of community assets, resources, civil-based organizations, and stakeholders is done to gain insight into the community culture and value in relation to COVID-19 vaccine. This will help to address the misconceptions while prompting COVID-19 vaccination sensitization activities that are relevant to each community. It is required that policy makers understand that the adoption of a comprehensive grassroots approach lends a voice to the community and helps to utilize community-initiated and community-driven ideas on promoting COVID-19 vaccine acceptance.