Health Promot Perspect. 2021;11(4): 492-497.
doi: 10.34172/hpp.2021.62
  Abstract View: 75
  PDF Download: 78

Original Article

The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study

Elnaz Vaghef-Mehrabani 1 ORCID logo, Azimeh Izadi 2, Mehrangiz Ebrahimi-Mameghani 3* ORCID logo

1 1Postdoctoral Associate, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Canada
2 Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3 Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Mehrangiz Ebrahimi-Mameghani, Email: ebrahimimamagani@ tbzmed.ac.ir


Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS.

Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m2 ) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n=75) and their age-matched non-depressed controls (n=150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured.

Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P<0.05). FBS was significantly correlated with BDI-II scores (r=0.158, P=0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P<0.001). Overall, MDD was not significantly associated with MetS in our study (OR=0.848, 95% CI: 0.484, 1.487; P=0.566).

Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.

Keywords: Insulin resistance, Major depressive disorder, Malondialdehyde, Metabolic syndrome, Obesity, Oxidative stress
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Submitted: 17 Dec 2020
Accepted: 27 Jul 2021
ePublished: 19 Dec 2021
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