Street vending practices are common in Africa and cater to a large portion of the continent’s population. Since the identification of coronavirus disease 2019 (COVID-19) in Africa, various governments have implemented measures to control the spread of infection. These measures may have an adverse effect on street vending practices. This paper demonstrates the extent to which COVID-19 measures of control and prevention affects street vending practices in Africa and how it can be remedied. There has been reduced economic growth and increased hunger among individuals involved in street vending practices due to the prohibitions put in place by governments. Measures directed at curbing the spread of the virus inadvertently affect street vending practices and vendors. Current and future pandemic response plans should reflect the integration of measures directed at reducing potential hardship and a further economic set back for individuals involved in street vending practices.