Submitted: 13 Jul 2014
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Health Promot Perspect. 2014;4(1): 90-97.
doi: 10.5681/hpp.2014.012
PMID: 25097842
PMCID: PMC4122033
  Abstract View: 894
  PDF Download: 563

Original Research

Effects of Sesame Seed Supplementation on Lipid Profile and Oxidative Stress Biomarkers in Patients with Knee Osteoarthritis

Mahdieh Khadem Haghighian, Beitollah Alipoor * , Bina Eftekhar Sadat, Aida Malek Mahdavi, Abdolvahab Moghaddam, Amir-Mansour Vatankhah


Background: This study was designed to assess the effect of sesame seed on lipid profile and oxidative stress biomarkers in knee osteoarthritis (OA) patients. Methods: Fifty patients with knee OA were allocated into two groups receiving 40 g of sesame seed daily along with standard medical therapy (n=25) or stan­dard treatment (n=25) for two months. Serum total antioxidant capacity, ma­londialdehyde (MDA) and lipid profile (total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides) were measured. Results: After the intervention period two months of study, serum TC, LDL-cholesterol and MDA decreased significantly in the sesame group (P<0.05), while no significant difference in serum values of lipid profile and oxidative stress parameters was seen in the control group (P>0.05). There was no signifi­cant difference in pre and post-treatment values of lipid profile and oxidative parameters between the two groups (P>0.05). Conclusion: Current study showed a positive effect of sesame seed in improv­ing lipid profile and oxidative stress in patients with knee OA and indicated the fact that sesame seed might be of help to reduce oxidative stress in OA patients.
Keywords: Sesame, Oxidative stress, Antioxidant, Lipid profile, Osteoarthritis
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