Tabriz University of Medical Sciences Health Promotion Perspectives 2228-6497 3 2 2013 12 31 Lipid Profile In Relation To Anthropometric Indices and Insulin Resistance in Overweight Women with Polycystic Ovary Syndrome 206 216 10.5681/hpp.2013.024 EN Maryam Saghafi-Asl Saeed Pirouzpanah Mehranghiz Ebrahimi-Mameghani Mohammad Asghari-Jafarabad4 Soudabeh Aliashrafi1 Bita Sadein Journal Article 10.5681/hpp.2013.024 2014 01 08 Background: The present study was aimed to investigate lipid profile in relation to anthropometric indices and insulin resistance in overweight or obese women with polycystic ovary syndrome (PCOS). Methods: In this cross-sectional study, lipid profile and anthropometric indices including body mass index (BMI), waist and hip circumference, waist to hip ratio (WHR), and waist to height ratio (WHtR) were evaluated in 63 overweight or obese PCOS patients subdivided into insulin-resistant (IR) and noninsulin-resistant (NIR) groups. IR was defined as homeostasis model of insulin resistance (HOMA-IR) ≥3.8.Results: Fasting insulin concentration and HOMA-IR were higher (P<0.001) and high-density lipoprotein cholesterol (P=0.012) was lower in IR group. All of the anthropometric measures other than WHR and BMI showed significant correlations with several lipid parameters. Amongst, WHtR showed the strongest correlation with total cholesterol (TC) (r=0.37; P=0.004) and low-density lipoprotein cholesterol (LDL-C) (r=0.33; P=0.011) in the whole PCOS patients. Conclusion: Anthropometric characteristics (especially BMI and hip circumference) are more important parameters correlated to lipid profile than IR in overweight or obesePCOS patients, confirming the importance of early treatment of obesity to prevent dyslipidemia in the future.