Abstract
Background: There are few studies on the
vitamin D status in preeclamptic women. The objective of this case-control
study was to determine vitamin D status, in preeclamptic women and compare it
with that of healthy pregnant controls.
Methods: Forty
preeclamptic women, aged 18 to 45yr and forty age- and pregnancy
weight-matched
healthy controls participated in the study. Serum 25-hydroxy
vitamin D (25(OH)D) levels were measured and its levels of <10,
10-30, 30-90 and >90 nanogram per milliliter (ng/ml) were considered
as vitamin D deficiency, insufficiency, sufficiency, and toxicity,
respectively.
Results: Sixty and forty percent of preeclamptic
women were vitamin D deficient and insufficient, while in the control group they
were 10% and 90%, respectively. No significant difference was found in the
median intake of vitamin D between preeclamptic and non preeclamptic women
(1.45 and 1.20µg/day respectively), but serum 25(OH)D concentration was
significantly lower in preeclamptic cases compared to controls (10.09 ± 6.66
and 15.73 ± 5.85ng /ml respectively, P= 0.002) .
Conclusion: Vitamin D deficiency is
common among preeclamptic and non-preeclamptic pregnant women in the north-west of Iran.
Preeclampsia can cause decreasing of serum level of 25(OH)D.