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Submitted: 19 Dec 2019
Accepted: 04 Jan 2020
ePublished: 30 Mar 2020
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Health Promot Perspect. 2020;10(2): 148-151.
doi: 10.34172/hpp.2020.24
PMID: 32296628
PMCID: PMC7146039
  Abstract View: 296
  PDF Download: 195
  Full Text View: 124

Original Article

Clostridium difficile in patients with nosocomial diarrhea, Northwest of Iran

Yalda Hematyar 1 ORCID logo, Tahereh Pirzadeh 2 ORCID logo, Seyyed Reza Moaddab 3 ORCID logo, Mohammad Ahangarzadeh Rezaee 2 ORCID logo, Mohammad Yousef Memar 1 ORCID logo, Hossein Samadi Kafil 4 * ORCID logo

1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Biotechnology Research Center, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Hossein Samadi Kafil, Email: kafilhs@tbzmed.ac.ir

Abstract

Background: Clostridium difficile is known as a prevalent pathogen leading to infections ranging from mild diarrhea to severe disease and death. The aim of the present study was to evaluate the incidence of C. difficile from inpatients with nosocomial diarrhea hospitalized in different wards in the northwest region of Iran.

Methods: In this cross-sectional study, 485 diarrheal stool samples were collected from 384 patients referred from different wards of Imam Reza, Sina and Pediatric hospitals, Tabriz and transferred to the laboratory from 25 March 2015 till 1 March 2018. Immuno-chromatographicassay for detection of toxins A and B of C. difficile was used for identification.

Results: Clostridium difficile was isolated from 24 (4.7%) out of 485 samples. Fifteen patients(62.5%) were males and 9 were females (37.5%). Twelve positive patients were from the gastrointestinal ward (50%), 5 patients (20.8%) from surgery ward, 3 patients from infectious disease ward (12.5%), 3 patients from rheumatology ward (12.5%) and 1 patient (4.1%) were collected from neurology ward. 95.3% of diarrhea samples had no signs from toxin A and B.

Conclusion: These results indicate most of infected patients were from the gastrointestinaland surgery wards which show a different pattern of infection compared to previous studies.The neurology department had the lowest rate of infection. C. difficile is a health threat afterantibiotic consumption and for health promotion, developing strategies for less antibioticconsumption and preventing these emerging infections is critical. The low rate of this infection shows improvement in knowledge and effect of stewardships in physicians.

Keywords: Clostridium difficile, Incidence, Immuno-chromatographic test, Toxin A, Toxin B protein, Diarrhea
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